ArticleBMC oral health2024
Characterization and biocompatibility of a bilayer PEEK-based scaffold for guiding bone regeneration.
Article in BMC oral health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- An Ion-Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR-Mediated Antibacterial Activity of PEEK.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Assessment of cell compatibility and antibacterial activity of nano-ZrOBMC oral health · 2026Article
- In silico study of a bilayer titanium dental implant with a porous titanium and hydroxyapatite composite outer layer for enhanced osseointegration.Scientific reports · 2026Article
- Graphene oxide-modified PEEK composites: Properties and applications in orthopaedic repair - A review.Journal of orthopaedic translation · 2026Review
- Polydopamine Nanocomposite Hydrogel for Drug Slow-Release in Bone Defect Repair: A Review of Research Advances.Gels (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundPolyetheretherketone (PEEK) is well known for its excellent physical-chemical properties and biosafety. The study aimed to open up a new method for clinical application of PEEK to reconstruct large-scale bone defects.
methodsA bilayer scaffold for bone regeneration was prepared by combining a sulfonated PEEK barrier framework (SPEEK) with a hydrogel layer loaded with aspirin (ASA) and nano-hydroxyapatite (nHAP) by the wet-bonding of Polydopamine (PDA).
resultsThe hydrogel was successfully adhered to the surface of SPEEK, resulting in significant changes including the introduction of bioactive groups, improved hydrophilicity, and altered surface morphology. Subsequent tests confirmed that the bilayer scaffold exhibited enhanced compression resistance and mechanical compatibility with bone compared to a single hydrogel scaffold. Additionally, the bilayer scaffold showed stable and reliable bonding properties, as well as excellent biosafety verified by cell proliferation and viability experiments using mouse embryo osteoblast precursor (MC3T3-E1) cells.
conclusionThe bilayer bone regeneration scaffold prepared in this study showed promising potential in clinical application for bone regeneration.
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Registered trials
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