Evidence map›Paper›PMID 39334009›Full record

ArticleBMC nephrology2024

Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.

Aleksandra Gliwińska, Marta Badeńska, Marta Dworak, Elżbieta Świętochowska, Andrzej Badeński, Omar Bjanid, Elżbieta Trembecka-Dubel, Aurelia Morawiec-Knysak, Maria Szczepańska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aleksandra GliwińskaDepartment of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland. brylkaalex@gmail.com.
Marta Badeńska *Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.
Marta Dworak *Department of Pediatric Nephrology with Dialysis Division for Children, Independent Public Clinical Hospital No. 1, Zabrze, 41-800, Silesia, Poland.
Elżbieta Świętochowska *Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.
Andrzej Badeński *Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.
Omar Bjanid *Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.
Elżbieta Trembecka-Dubel *Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.
Aurelia Morawiec-Knysak *Department of Pediatric Nephrology with Dialysis Division for Children, Independent Public Clinical Hospital No. 1, Zabrze, 41-800, Silesia, Poland.
Maria Szczepańska *Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, 40-055, Silesia, Poland.

Funding

Śląski Uniwersytet Medyczny w Katowicach KNW-1-161/N/9/KŚląski Uniwersytet Medyczny w Katowicach PCN-2-056/N/0/K
6 · The paper itself

Abstract

Patients suffering from chronic kidney disease (CKD) are particularly placed at risk of multiorgan complications. One of them is malnutrition, which adds up to a higher mortality factor among them. This study was designed to determine the usefulness of brain-derived neurotrophic factor (BDNF) and irisin assays in the assessment of CKD development. The study group included 28 children with CKD at stages 2-5 treated conservatively. The outcome of our study revealed decreased serum BDNF and irisin levels in CKD patients, whereas urine concentrations were increased for BDNF and decreased for irisin, comparing to healthy controls. There was a positive correlation between anthropometric measures and urine BDNF concentration, as well as anthropometric measures and both serum and urine irisin levels in the study group, however no dependence of the tested markers on the stage of CKD was observed. In recent years, a role of myokines was described as vital for maintaining metabolic homeostasis therefore we suspect a potential role of these multifaceted markers in detecting malnutrition in CKD children.

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorFibronectinsRenal Insufficiency, ChronicAdolescentChildChild, PreschoolFemaleHumansMalePilot ProjectsBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorFibronectinsFNDC5 protein, humanBrain-derived neurotrophic factorChronic kidney diseaseIrisinMalnutrition

Identifiers

PMID39334009
PMCPMC11430335

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.