Evidence map›Paper›PMID 39333881›Full record

Observational studyBMC cardiovascular disorders2024

Triglyceride-glucose index as a predictor of cardiac adverse events in acute coronary syndrome patients undergoing percutaneous coronary intervention: role of diabetes.

Amirmohammad Khalaji, Amir Hossein Behnoush, Yeganeh Pasebani, Ali Rafati, Tara Mahmoodi, Alireza Arzhangzadeh, Sima Shamshiri Khamene, Izat MohammadKhawajah, Mehdi Mehrani, Ali Vasheghani-Farahani and 7 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07130188 (The Significance of Triglyceride Index and TG/HDL-C Ratios as Predictors of Acute Coronary Syndromes in Young Population and the Complexity of Coronary Artery Disease), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07130188 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

The Significance of Triglyceride Index and TG/HDL-C Ratios as Predictors of Acute Coronary Syndromes in Young Population and the Complexity of Coronary Artery Disease

TypeobservationalSponsorAssiut UniversityRan2025 to 2026Enrolled130ConditionsTG Index, TG/HDL-C Ratio, Young PopulationArmsPCI
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Amirmohammad Khalaji *Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Amir Hossein Behnoush *Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Yeganeh PasebaniCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ali RafatiCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Tara MahmoodiCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Alireza ArzhangzadehDepartment of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sima Shamshiri KhameneCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Izat MohammadKhawajahCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mehdi MehraniCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ali Vasheghani-FarahaniCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Farzad MasoudkabirCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kimia NajafiHakim Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mani K AskariDepartment of Medicine, The University of Toledo Medical Center, Toledo, USA.
Anil HarrisonInternal Medicine, University of Central Florida/HCA Florida West Hospital, Pensacola, USA.
John R NelsonCalifornia Cardiovascular Institute, 7061 N. Whitney, Suite 101, Fresno, CA, 93720, USA.
Kaveh HosseiniCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran. kaveh_hosseini130@yahoo.com.
Adrian V HernandezHealth Outcomes, Policy, and Evidence Synthesis (HOPES) Group, University of Connecticut School of Pharmacy, Storrs, CT, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTriglyceride-glucose index (TyG), a surrogate marker of insulin resistance (IR), could be a potential prognostic marker in patients with acute coronary syndromes (ACS). We evaluated the effect of the TyG index on major adverse cardiac and cerebrovascular events (MACCE) in patients with ACS undergoing percutaneous coronary intervention (PCI).

methodsThis registry-based cohort study was conducted at Tehran Heart Center from 2015 to 2021 and the median follow-up duration was 378 days. The primary outcome was MACCE and the secondary outcomes were MACCE components: all-cause mortality, myocardial infarction, stroke, target vessel revascularization, target lesion revascularization, and coronary artery bypass grafting. For comparison among TyG quartiles (Q), the log-rank test was used. Unadjusted and adjusted hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to describe the association between TyG quartiles and MACCE. A subgroup of euglycemic patients was also evaluated.

resultsA total of 13,542 patients were included. Patients in the fourth TyG quartile (Q4) were younger, had higher mean BMI, and higher prevalence of hypertension, diabetes, and dyslipidemia. The adjusted Cox model showed that a 1-unit increment of the TyG index was associated with a significantly higher risk of MACCE (aHR 1.18, 95% CI 1.08 to 1.30, p < 0.001). Among TyG quartiles, there was a higher MACCE incidence in Q4 compared to Q1 (aHR 1.29, 95% CI 1.08 to 1.53, p = 0.005). In the euglycemic subgroup of the population, there was no significant association between MACCE incidence and a 1-unit increase in TyG or among TyG quartiles.

conclusionBased on our findings, while higher TyG levels and quartiles were associated with higher rates of MACCE in ACS, there was no such effect in the euglycemic population. If confirmed in future studies, these results can be beneficial for clinicians to risk stratify these patients with an easy-to-use index and determine clinical plans based on their risk.

Indexed as

Acute Coronary SyndromeBiomarkersBlood GlucoseDiabetes MellitusPercutaneous Coronary InterventionRegistriesTriglyceridesAgedFemaleHumansInsulin ResistanceIranMaleMiddle AgedPredictive Value of TestsRisk AssessmentBiomarkersBlood GlucoseTriglyceridesAcute coronary syndromeDiabetes MellitusInsulin resistancePercutaneous coronary interventionPrognosisTriglyceride-glucose index

Identifiers

PMID39333881
PMCPMC11430238

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.