ArticleThe journal of headache and pain2024
Improved polygenic risk prediction in migraine-first patients.
Article in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- What does a migraine aura look like?-A systematic review.The journal of headache and pain · 2025Pooled it
- Association between TNFa rs1800629 and migraine: Case-control study and updated meta-analysis.AIMS neuroscience · 2026Article
- Interaction between physical frailty and sleep quality on risk of migraine in later life: a cohort study of over 350,000 participants.BMC public health · 2025Article
- The interictal transcriptomic map of migraine without aura.The journal of headache and pain · 2025Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundRecent meta-analyses estimated 14.6% and 11.2% SNP-based heritability of migraine, compared to twin-heritability estimates of 30-60%. This study aimed to investigate heritability estimates in "migraine-first" individuals, patients for whom G43 (migraine with or without aura) was their first medical diagnosis in their lifetime.
findingsUsing data from the UK Biobank (N = 199,929), genome-wide association studies (GWAS) were conducted on 6,139 migraine-first patients and 193,790 healthy controls. SNP-based heritability was estimated using SumHer, yielding 19.37% (± 0.019) for all SNPs and 21.31% (± 0.019) for HapMap3 variants, substantially surpassing previous estimates. Key risk loci included PRDM16, FHL5, ASTN2, STAT6/LRP1, and SLC24A3, and pathway analyses highlighted retinol metabolism and steroid hormone biosynthesis as important pathways in these patients.
conclusionsThe findings underscore that excluding comorbidities at onset time can enhance heritability estimates and genetic signal detection, significantly reducing the extent of "missing heritability" in migraine.
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Registered trials
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