Evidence map›Paper›PMID 39333474›Full record

ArticleNature communications2024

CD38 in SLE CD4 T cells promotes Ca

Eri Katsuyama, Morgane Humbel, Abel Suarez-Fueyo, Abhigyan Satyam, Nobuya Yoshida, Vasileios C Kyttaris, Maria G Tsokos, George C Tsokos

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. RAB4A DRIVES PROINFLAMMATORY CD4Research square · 2025
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eri Katsuyama *Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Morgane Humbel *Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Abel Suarez-FueyoDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Abhigyan SatyamDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Nobuya YoshidaDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.
Vasileios C KyttarisDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.ORCID 0000-0001-7652-3826
Maria G TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA.ORCID 0000-0001-8072-1358
George C TsokosDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA. gtsokos@bidmc.harvard.edu.ORCID 0000-0001-9589-2360

Funding

LYMPHOCYTE SIGNALING DEFECTS IN PATIENTS WITH LUPUSR01AI042269 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI TSOKOS, GEORGE C · 1998 to 2017
$6.8M
T cells in LupusR01AI148161 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI TSOKOS, GEORGE C · 2020 to 2024
$2.2M
NIAID NIH HHS R01 AI042269NIAID NIH HHS R01 AI148161U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) RO1AI42269
6 · The paper itself

Abstract

CD38 has emerged as a potential therapeutic target for patients with systemic lupus erythematosus (SLE) but it is not known whether CD38 alters CD4

Indexed as

ADP-ribosyl Cyclase 1CalciumCD4-Positive T-LymphocytesCell MembraneInterleukin-2Lupus Erythematosus, SystemicFemaleHumansJurkat CellsMembrane GlycoproteinsPhospholipase C gammaADP-ribosyl Cyclase 1CalciumCD38 protein, humanIL2 protein, humanInterleukin-2Membrane GlycoproteinsPhospholipase C gamma

Identifiers

PMID39333474
PMCPMC11436706

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.