Evidence map›Paper›PMID 39333414›Full record

ReviewNature reviews. Microbiology2025

Microbial extracellular polymeric substances in the environment, technology and medicine.

Hans-Curt Flemming, Eric D van Hullebusch, Brenda J Little, Thomas R Neu, Per H Nielsen, Thomas Seviour, Paul Stoodley, Jost Wingender, Stefan Wuertz

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

  1. Review
  2. Beyond Bactericidal: Plasma Surface Engineering to Defeat Food Matrix-Conditioning Layers.Comprehensive reviews in food science and food safety · 2026
    Review
  3. Review
  4. Diversification of biofilm architecture among freshwaterApplied and environmental microbiology · 2026
    Article
  5. Article
  6. Article
  7. Contrasting the dynamic changes of carotenoid accumulation in Rhodotorula mucilaginosa under Pb and Cd stress.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Molecular Regulation of Biofilm Development inPathogens (Basel, Switzerland) · 2026
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hans-Curt FlemmingSingapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore. hc.flemming@uni-due.de.ORCID http://orcid.org/0000-0002-3670-9236
Eric D van HullebuschUniversité Paris Cité, Institut de Physique du Globe de Paris, CNRS, Paris, France.ORCID http://orcid.org/0000-0002-1519-1925
Brenda J LittleCorrosion Consulting, Montgomery, TX, USA.
Thomas R NeuDepartment of River Ecology, Helmholtz Centre for Environmental Research - UFZ, Magdeburg, Germany.ORCID http://orcid.org/0000-0001-6990-8787
Per H NielsenCenter for Microbial Communities, Department of Chemistry and Bioscience, Aalborg University, Aalborg, Denmark.ORCID http://orcid.org/0000-0002-6402-1877
Thomas SeviourAarhus University Centre for Water Technology, Department of Biological and Chemical Engineering, Aarhus University, Aarhus, Denmark.ORCID http://orcid.org/0000-0002-8816-9796
Paul StoodleyDepartment of Microbial Infection and Immunity and the Department of Orthopaedics, the Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6069-273X
Jost WingenderUniversity of Duisburg-Essen, Faculty of Chemistry, Environmental Microbiology and Biotechnology, Essen, Germany.
Stefan WuertzSingapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3415-6199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial biofilms exhibit a self-produced matrix of extracellular polymeric substances (EPS), including polysaccharides, proteins, extracellular DNA and lipids. EPS promote interactions of the biofilm with other cells and sorption of organics, metals and chemical pollutants, and they facilitate cell adhesion at interfaces and ensure matrix cohesion. EPS have roles in various natural environments, such as soils, sediments and marine habitats. In addition, EPS are relevant in technical environments, such as wastewater and drinking water treatment facilities, and water distribution systems, and they contribute to biofouling and microbially influenced corrosion. In medicine, EPS protect pathogens within the biofilm against the host immune system and antimicrobials, and emerging evidence suggests that EPS can represent potential virulence factors. By contrast, EPS yield a wide range of valuable products that include their role in self-repairing concrete. In this Review, we aim to explore EPS as a functional unit of biofilms in the environment, in technology and in medicine.

Indexed as

BacteriaBiofilmsEnvironmental MicrobiologyExtracellular Polymeric Substance MatrixBiofoulingHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.