Evidence map›Paper›PMID 39333372›Full record

ArticleCardiovascular and interventional radiology2024

Comparison of Chemotherapy Combined with Percutaneous Electroporation and Chemotherapy Alone in the Management of Locally Advanced Gallbladder Carcinoma (GBC): A Study Protocol.

N Kalra, H Bhujade, A Baloji, D Khosla, S Samra, R Srinivasan, P Gupta, H Singh, V Gupta, R Kapoor and 4 more

Abstract readClinical Trial Protocol
PubMed Publisher
In one paragraph

Article in Cardiovascular and interventional radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

N KalraDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India. navkal2004@yahoo.com.
H BhujadeDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
A BalojiDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
D KhoslaDepartment of Radiotherapy and Oncology, PGIMER, Chandigarh, India.
S SamraDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
R SrinivasanDepartment of Cytology and Gynecological Pathology, PGIMER, Chandigarh, India.
P GuptaDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.
H SinghDepartment of Gastrointestinal Surgery, PGIMER, Chandigarh, India.
V GuptaDepartment of Gastrointestinal Surgery, PGIMER, Chandigarh, India.
R KapoorDepartment of Radiotherapy and Oncology, PGIMER, Chandigarh, India.
D DahiyaDepartment of General Surgery, PGIMER, Chandigarh, India.
R GuptaDepartment of Gastrointestinal Surgery, PGIMER, Chandigarh, India.
K KishoreDepartment of Biostatistics, PGIMER, Chandigarh, India.
M SandhuDepartment of Radiodiagnosis and Imaging, PGIMER, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aims to evaluate the feasibility and efficacy of chemotherapy combined with irreversible electroporation (IRE) in patients with locally advanced gallbladder carcinoma (GBC) presenting as gallbladder masses. MATERIALS AND

methodsPatients with unresectable GBC masses of size greater than 2 cm and less than 6 cm without evidence of distant metastases and with no contraindication to general anaesthesia will be enrolled in the study. They will be randomized using computer generated table into two arms with 1:1 allocation ratio to include 15 patients in each group. Group I will be the chemotherapy alone arm and Group II will be the combined image-guided irreversible electroporation of the tumour and chemotherapy arm. The primary outcome assessed shall be the clinical benefit rate (complete response, CR; partial response, PR and stable disease, SD) based on the mRECIST criteria and overall survival. The secondary outcome shall be feasibility and safety of the procedure and quality of life pre and post procedure. The quality of life will be assessed by a questionnaire as given by EORTC-Quality of Life Group before starting therapy and 4 weeks after completion of therapy. EXPECTED GAIN OF KNOWLEDGE: The combined local and systemic effects of irreversible electroporation and systemic chemotherapy respectively may improve the outcomes in inoperable cases of gallbladder carcinoma.

trial registrationClinical Trials Registry - India ( https://ctri.nic.in/Clinicaltrials/advancesearchmain.php ). Identifier: CTRI/2021/05/033803. Primary Register of the International Clinical Trials Registry Platform (WHO ICTRP) ( http://www.who.int/ictrp/search/en/ ).

Indexed as

ElectroporationGallbladder NeoplasmsAdultAntineoplastic AgentsCombined Modality TherapyElectrochemotherapyFeasibility StudiesFemaleHumansMaleMiddle AgedQuality of LifeTreatment OutcomeAntineoplastic AgentsAblationChemotherapyIrreversible electroporationUnresectable gallbladder carcinoma

Identifiers

PMID39333372

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.