Evidence map›Paper›PMID 39333344›Full record

ArticleScientific reports2024

Low bias charge transport in DNA.

Maciej Wiesner, Jan Barciszewski, Agnieszka Belter, Andrzej Sierakowski, Adrian Drzazga, Marcin K Chmielewski

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maciej Wiesner *Faculty of Physics, Adam Mickiewicz University, Uniwersytetu Poznanskiego 2, Poznan, 61-614, Poland. mwiesner@amu.edu.pl.
Jan Barciszewski *NanoBioMedical Centre, Adam Mickiewicz University, Wszechnicy Piastowskiej 3, Poznan, 61-614, Poland.
Agnieszka Belter *Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, Poznan, 61-704, Poland.
Andrzej SierakowskiSieć Badawcza Łukasiewicz - Instytut Mikroelektroniki i Fotoniki, al. Lotników 32/46, Warsaw, 02-668, Poland.
Adrian DrzazgaTespol Sp. z o.o. ul, Klecińska 125, Wrocław, 54-413, Poland.
Marcin K ChmielewskiInstitute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, Poznan, 61-704, Poland. chmielewskimk@ibch.poznan.pl.

Funding

Ministerstwo Edukacji i Nauki 7219/IA/SP/2021
6 · The paper itself

Abstract

The low-bias current-voltage technique was utilized to study charge transport in single-stranded DNA (ssDNA), assessing the method's effectiveness for future studies aimed at estimating the degree of mutation or DNA damage. In the paper, we showed that charge carrier transfer processes in ssDNA can be precisely monitored using low-bias currents. We used negative differential resistance and the Fowler-Nordheim model to differentiate the charge transport mechanisms observed in a device composed of gold electrode-thiol-ssDNA junctions. It was possible to distinguish the processes at the two junctions (Au/thiol and thiol/DNA) due to their distinct current-voltage characteristics. We observed positive charge carrier tunneling, which we attribute to oxidation and reduction processes in the nucleobases of the ssDNA. Our results suggest that even minor changes in DNA chains can be accurately detected using the described methodology.

Indexed as

DNA, Single-StrandedDNAElectrodesGoldOxidation-ReductionSulfhydryl CompoundsDNADNA, Single-StrandedGoldSulfhydryl CompoundsDifferential resistanceDNAElectron transportEmissionHole transportMolecular junctionTunneling

Identifiers

PMID39333344
PMCPMC11436907

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.