Evidence map›Paper›PMID 39333278›Full record

ArticleScientific reports2024

Altered functional connectivity in preterm neonates with intraventricular hemorrhage assessed using functional near-infrared spectroscopy.

Lilian M N Kebaya, Lingkai Tang, Talal Altamimi, Alexandra Kowalczyk, Melab Musabi, Sriya Roychaudhuri, Homa Vahidi, Paige Meyerink, Sandrine de Ribaupierre, Soume Bhattacharya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lilian M N Kebaya *Neonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Lingkai Tang *Biomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.
Talal AltamimiNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Alexandra KowalczykNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Melab MusabiNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Sriya RoychaudhuriNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Homa VahidiNeuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Paige MeyerinkNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Sandrine de RibaupierreNeuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Soume BhattacharyaNeonatal-Perinatal Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Leandro Tristao Abi Ramia de MoraesMedical Imaging, London Health Sciences Centre, Western University, London, ON, Canada.
Keith St LawrenceBiomedical Engineering, Faculty of Engineering, Western University, London, ON, Canada.
Emma G DuerdenNeuroscience, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada. eduerden@uwo.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intraventricular hemorrhage (IVH) is a common neurological injury following very preterm birth. Resting-state functional connectivity (RSFC) using functional magnetic resonance imaging (fMRI) is associated with injury severity; yet, fMRI is impractical for use in intensive care settings. Functional near-infrared spectroscopy (fNIRS) measures RSFC through cerebral hemodynamics and has greater bedside accessibility than fMRI. We evaluated RSFC in preterm neonates with IVH using fNIRS and fMRI at term-equivalent age, and compared fNIRS connectivity between healthy newborns and those with IVH. Sixteen very preterm born neonates were scanned with fMRI and fNIRS. Additionally, fifteen healthy newborns were scanned with fNIRS. In preterms with IVH, fNIRS and fMRI connectivity maps were compared using Euclidean and Jaccard distances. The severity of IVH in relation to fNIRS-RSFC strength was examined using generalized linear models. fNIRS and fMRI RSFC maps showed good correspondence. Connectivity strength was significantly lower in healthy newborns (p-value = 0.023) and preterm infants with mild IVH (p-value = 0.026) compared to infants with moderate/severe IVH. fNIRS has potential to be a new bedside tool for assessing brain injury and monitoring cerebral hemodynamics, as well as a promising biomarker for IVH severity in very preterm born infants.

Indexed as

Infant, PrematureMagnetic Resonance ImagingSpectroscopy, Near-InfraredCerebral HemorrhageFemaleHemodynamicsHumansInfant, NewbornMaleFunctional connectivityFunctional near-infrared spectroscopyIntraventricular hemorrhage

Identifiers

PMID39333278
PMCPMC11437059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.