ArticleScientific reports2024
Socialization causes long-lasting behavioral changes.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Environmental modulation of social isolation-induced sleep loss inbioRxiv : the preprint server for biology · 2026Article
- GIGEM (Group Isolation Gauge Effect Metrics), A Software Suite for Analyzing Social Isolation-Induced Sleep Loss and Multi-Batch Experiments inbioRxiv : the preprint server for biology · 2025Article
- A memory transcriptome time course reveals essential long-term memory transcription factors.Nature communications · 2025Article
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Authors and funding
8 authors.
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Abstract
In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human, impacting aggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
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