ArticleNature communications2024
Strongly deleterious mutations influence reproductive output and longevity in an endangered population.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Reduced Genetic Load and Inbreeding in Reintroduced African Wild Dogs Reflect the Benefits of Admixture.Molecular ecology · 2026Article
- Genomic signatures of population isolation in an endangered European rodent.BMC genomics · 2026Article
- Genetic legacy and recent cross of two ancient lineages underlie the rebound of the world's rarest primate.Science advances · 2026Article
- Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot.Molecular ecology · 2026Article
- Genome Variation in Three Anthophora Bee Species Reflects Divergent Demographic Histories.Molecular ecology · 2025Article
- Conservation genomics of two endangered buntings reveal genetic diversity before and after severe population declines.BMC biology · 2025Article
- Predicted deleterious mutations reveal the genetic architecture of male reproductive success in a lekking bird.Nature ecology & evolution · 2025Article
- Urban Life Shapes Genetic Diversity in the Green Anole, Anolis carolinensis.Molecular ecology · 2025Article
- Inbreeding reduces fitness in spatially structured populations of a threatened rattlesnake.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative Population Genomics Reveal the Determinants of Genome Erosion in Two Sympatric Neotropical Falcons.Molecular ecology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Inbreeding depression has been documented in various fitness traits in a wide range of species and taxa, however, the mutational basis is not yet well understood. We investigate how putatively deleterious variation influences fitness and is shaped by individual ancestry by re-sequencing complete genomes of 37 individuals in a natural arctic fox (Vulpes lagopus) population subjected to both inbreeding depression and genetic rescue. We find that individuals with high proportion of homozygous loss of function genotypes (LoFs), which are predicted to exert a strong effect on fitness, generally have lower lifetime reproductive success and live shorter lives compared with individuals with lower proportion of LoFs. We also find that juvenile survival is negatively associated with the proportion of homozygous missense genotypes and positively associated with genome wide heterozygosity. Our results demonstrate that homozygosity of strongly and moderately deleterious mutations can be an important cause of trait specific inbreeding depression in wild populations, and mark an important step towards making more informed decisions using applied conservation genetics.
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Registered trials
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