ArticleNature communications2024
Cryo-EM structure of small-molecule agonist bound delta opioid receptor-G
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
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Who cites it
11 citing papers in PubMed.
- Steric control of signaling bias in the immunometabolic receptor GPR84.Nature communications · 2026Article
- Structure-guided allosteric modulation of the delta opioid receptor.Nature communications · 2026Article
- Molecular mechanism of allosteric modulation of opioid receptors.Signal transduction and targeted therapy · 2026Article
- Structural and dynamic studies uncover a distinct allosteric modulatory site at the µ-opioid receptor.Nature communications · 2026Article
- Mechanistic insights into the therapeutic properties of delta opioid receptor.Science advances · 2026Article
- Structural and dynamic studies uncover a distinct allosteric modulatory site at the μ-opioid receptor.bioRxiv : the preprint server for biology · 2025Article
- Investigation of the Binding Characteristics of Agonists and Various Antagonists Targeting Histamine 1 Receptor.Pharmaceutical research · 2025Article
- Delta opioid receptors: Overlooked outlier or the next big thing.Current opinion in pharmacology · 2025Review
- Pharmacology and Toxicology of Opioids-Recent Advances and New Perspectives.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Fentanyl-Antibody Interaction as a Novel Strategy against Opiates and Opioids Abuse.Journal of medicinal chemistry · 2025Review
- Structure-guided design of partial agonists at an opioid receptor.Nature communications · 2025Article
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Authors and funding
18 authors.
Lin Cheng *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhuang Miao *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sicen Liu *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhe Li *School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China.
Hong Fu *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chanjuan Xu *Cellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.ORCID 0000-0002-5640-1896
Shilong Hu *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Chang Zhao *Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0002-8273-1338
Yuxuan LiuCellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Tiantian ZhaoDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Wencheng LiuDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Heli WangDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Runduo LiuSchool of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, P. R. China.
Wei YanDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID 0000-0001-9825-0689
Xiangdong TangSleep Medicine Center, Mental Health Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Jianfeng LiuCellular Signaling Laboratory, International Research Center for Sensory Biology and Technology of MOST, Key Laboratory of Molecular Biophysics of MOE, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei, China. jfliu@mail.hust.edu.cn.ORCID 0000-0002-0284-8377
Zhenhua ShaoDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. zhenhuashao@scu.edu.cn.ORCID 0000-0001-7204-801X
Bowen KeDepartment of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China. bowenke@scu.edu.cn.ORCID 0000-0002-0328-7719
Funding
Department of Science and Technology of Sichuan Province (Sichuan Provincial Department of Science and Technology) 2023ZYD0168Department of Science and Technology of Sichuan Province (Sichuan Provincial Department of Science and Technology) 2024NSFJQ0052Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021ZD0201900Ministry of Science,Technology and Research (Ministry of Technology & Research) 2019YFA0508800National Natural Science Foundation of China (National Science Foundation of China) 31972916, T2221004, 31972916National Natural Science Foundation of China (National Science Foundation of China) 32330049, 82320108021National Natural Science Foundation of China (National Science Foundation of China) 32371288, 32100988National Natural Science Foundation of China (National Science Foundation of China) 323B2038National Natural Science Foundation of China (National Science Foundation of China) 82271190, 32100965National Natural Science Foundation of China (National Science Foundation of China) 82425054, 82273784
Abstract
Delta opioid receptor (δOR) plays a pivotal role in modulating human sensation and emotion. It is an attractive target for drug discovery since, unlike Mu opioid receptor, it is associated with low risk of drug dependence. Despite its potential applications, the pharmacological properties of δOR, including the mechanisms of activation by small-molecule agonists and the complex signaling pathways it engages, as well as their relation to the potential side effects, remain poorly understood. In this study, we use cryo-electron microscopy (cryo-EM) to determine the structure of the δOR-G
Indexed as
Cryoelectron MicroscopyReceptors, Opioid, deltaAnimalsBenzamidesbeta-ArrestinsBinding SitesDrug DiscoveryGTP-Binding Protein alpha Subunits, Gi-GoHEK293 CellsHumansLigandsMaleMicePiperazinesProtein BindingSignal Transduction4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamideBenzamidesbeta-ArrestinsGTP-Binding Protein alpha Subunits, Gi-GoLigandsPiperazinesReceptors, Opioid, deltaSmall Molecule Libraries
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.