ReviewGenome biology and evolution2024
Modeling Substitution Rate Evolution across Lineages and Relaxing the Molecular Clock.
Review in Genome biology and evolution, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- When Complex Models Fit the Wrong Mechanistic Complexity in Phylogenomic Analysis.Journal of molecular evolution · 2026Article
- Dislodging the drift barrier: Why do mutation rates vary?Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Phylogenetic analysis suggests early divergence followed by convergent morphological evolution in thePhytoKeys · 2025Article
- Challenges in Assembling the Dated Tree of Life.Genome biology and evolution · 2024Article
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Authors and funding
2 authors.
Funding
Abstract
Relaxing the molecular clock using models of how substitution rates change across lineages has become essential for addressing evolutionary problems. The diversity of rate evolution models and their implementations are substantial, and studies have demonstrated their impact on divergence time estimates can be as significant as that of calibration information. In this review, we trace the development of rate evolution models from the proposal of the molecular clock concept to the development of sophisticated Bayesian and non-Bayesian methods that handle rate variation in phylogenies. We discuss the various approaches to modeling rate evolution, provide a comprehensive list of available software, and examine the challenges and advancements of the prevalent Bayesian framework, contrasting them to faster non-Bayesian methods. Lastly, we offer insights into potential advancements in the field in the era of big data.
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