Evidence map›Paper›PMID 39332833›Full record

ArticleCanadian journal of surgery. Journal canadien de chirurgie

False-negative sentinel lymph node biopsy for melanoma: a single-surgeon experience.

Julia Downey, Kimberly DeVries, Ian Marie Lano, Christopher Baliski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of surgery. Journal canadien de chirurgie. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julia DowneyFrom the Department of Surgical Oncology, BC Cancer-Sindi Ahluwalia Hawkins Centre, Kelowna, B.C. (Downey, Baliski); the Cancer Surveillance and Outcomes, BC Cancer, Vancouver, B.C. (DeVries); the Department of Pathology, Kelowna General Hospital, Kelowna, B.C. (Lano); the University of British Columbia Southern Medical Program, Kelowna, B.C. (Baliski).
Kimberly DeVriesFrom the Department of Surgical Oncology, BC Cancer-Sindi Ahluwalia Hawkins Centre, Kelowna, B.C. (Downey, Baliski); the Cancer Surveillance and Outcomes, BC Cancer, Vancouver, B.C. (DeVries); the Department of Pathology, Kelowna General Hospital, Kelowna, B.C. (Lano); the University of British Columbia Southern Medical Program, Kelowna, B.C. (Baliski).
Ian Marie LanoFrom the Department of Surgical Oncology, BC Cancer-Sindi Ahluwalia Hawkins Centre, Kelowna, B.C. (Downey, Baliski); the Cancer Surveillance and Outcomes, BC Cancer, Vancouver, B.C. (DeVries); the Department of Pathology, Kelowna General Hospital, Kelowna, B.C. (Lano); the University of British Columbia Southern Medical Program, Kelowna, B.C. (Baliski).
Christopher BaliskiFrom the Department of Surgical Oncology, BC Cancer-Sindi Ahluwalia Hawkins Centre, Kelowna, B.C. (Downey, Baliski); the Cancer Surveillance and Outcomes, BC Cancer, Vancouver, B.C. (DeVries); the Department of Pathology, Kelowna General Hospital, Kelowna, B.C. (Lano); the University of British Columbia Southern Medical Program, Kelowna, B.C. (Baliski) cbaliski@bccancer.bc.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe status of the regional lymph node basin is of prognostic importance in patients with melanoma, making the performance of sentinel lymph node biopsies (SLNBs) a key component of patient care management, particularly with the advent of immunotherapy for adjuvant treatment. The primary goal of our study was to assess the false-negative rate of SLNBs among patients with melanoma.

methodsWe conducted a retrospective review of patients with melanoma undergoing SLNB by a single surgeon between Jan. 1, 2005, and Dec. 31, 2020. We extracted and cross-referenced patient demographic and pathologic information.

resultsDuring the study period, 501 patients underwent an SLNB. Of these, 97 (19.4%) patients had pathologically positive sentinel lymph nodes and 404 (80.6%) patients had negative results. The latter were subject to further review; 84 (20.8%) patients subsequently developed recurrence, with 25 (6.2%) recurrences within the primary nodal basin. Isolated regional recurrence occurred in 11 (2.7%) patients and conjunction with a false-negative rate was 10.2%. Unadjusted recurrence rates were similar across each lymph node basin, including the axilla (2.7%), groin (3.6%), and neck (1.4%).

conclusionThe false-negative SLNB rate was 10.2% for isolated regional recurrences. These findings need to be considered in the era of using adjuvant systemic therapy for patients with melanoma.

Indexed as

MelanomaSentinel Lymph Node BiopsySkin NeoplasmsAdultAgedAged, 80 and overFalse Negative ReactionsFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective Studies

Identifiers

PMID39332833
PMCPMC11444684

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.