Evidence map›Paper›PMID 39332797›Full record

ArticleExperimental neurology2024

Combined biomaterial scaffold and neuromodulation strategy to promote tissue repair and corticospinal connectivity after spinal cord injury in a rodent model.

P T J A Williams, Eva Schelbaum, Chaimae Ahmanna, Heather Alexander, Kadia Kanté, Sylvia Soares, Hisham Sharif, Fatiha Nothias, John H Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

P T J A WilliamsCity University of New York School of Medicine, Center for Discovery and Innovation, New York, USA.
Eva SchelbaumCity University of New York School of Medicine, Center for Discovery and Innovation, New York, USA.
Chaimae AhmannaNeuroscience Paris Seine NPS, CNRS UMR8246, INSERM U1130, UM119, Institut de Biologie Paris Seine IBPS, Sorbonne Université Sciences, Campus UPMC, 75005 Paris, France; Medjeduse, 57 Rue Richelieu, 75002 Paris, France.
Heather AlexanderCity University of New York School of Medicine, Center for Discovery and Innovation, New York, USA.
Kadia KantéNeuroscience Paris Seine NPS, CNRS UMR8246, INSERM U1130, UM119, Institut de Biologie Paris Seine IBPS, Sorbonne Université Sciences, Campus UPMC, 75005 Paris, France; Medjeduse, 57 Rue Richelieu, 75002 Paris, France.
Sylvia SoaresNeuroscience Paris Seine NPS, CNRS UMR8246, INSERM U1130, UM119, Institut de Biologie Paris Seine IBPS, Sorbonne Université Sciences, Campus UPMC, 75005 Paris, France.
Hisham SharifCity University of New York School of Medicine, Center for Discovery and Innovation, New York, USA.
Fatiha NothiasNeuroscience Paris Seine NPS, CNRS UMR8246, INSERM U1130, UM119, Institut de Biologie Paris Seine IBPS, Sorbonne Université Sciences, Campus UPMC, 75005 Paris, France. Electronic address: fatiha.nothias@upmc.fr.
John H MartinCity University of New York School of Medicine, Center for Discovery and Innovation, New York, USA; Graduate Center of the City University of New York School, New York, USA. Electronic address: jmartin@med.cuny.edu.

Funding

Research Center in Minority Institutions (RCMI) at City CollegeU54MD017979 · NIMHD · CITY COLLEGE OF NEW YORK · PI M. Felice Marina GHILARDI · 2024 to 2026
$15.9M
Lesion and Activity Dependent Corticospinal Tract PlasticityR01NS064004 · NINDS · RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK D/B/A RF CUNY - CUNY SCHOOL OF MEDICINE · PI John H Martin · 2009 to 2026
$5.2M
Combined Biomaterial and Neuromodulatory Approach to Promote Axonal Outgrowth and Connections After Cervical SCIR21NS116550 · NINDS · CITY COLLEGE OF NEW YORK · PI MARTIN, JOHN H · 2021 to 2022
$423k
NIMHD NIH HHS U54 MD017979NINDS NIH HHS R01 NS064004NINDS NIH HHS R21 NS116550
6 · The paper itself

Abstract

Spinal cord injury (SCI) damages the trauma site, leading to progressive and secondary structural defects rostral and caudal to the injury. Interruption of ascending and descending pathways produce motor, sensory, and autonomic impairments, driving the need for effective therapies. In this study, we address lesion site repair and promoting descending projections using a combined biomaterial-neuromodulation strategy in a rat model of cervical contusion SCI. To promote tissue repair, we used Chitosan fragmented physical hydrogel suspension (C

Indexed as

Pyramidal TractsRats, Sprague-DawleySpinal Cord InjuriesTissue ScaffoldsAnimalsBiocompatible MaterialsChitosanDisease Models, AnimalFemaleHydrogelsMotor CortexNerve RegenerationRatsBiocompatible MaterialsChitosanHydrogelsAxon diebackAxon sproutingChitosanCorticospinal tractGFAPGlial scarHydrogelRodentSpinal direct current stimulationtheta burst stimulationTissue engineering

Identifiers

PMID39332797
PMCPMC12366954

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.