Evidence map›Paper›PMID 39332673›Full record

ArticleThe American journal of pathology2024

Endoplasmic Reticulum Stress Delays Choroid Development in the HCAR1 Knockout Mouse.

Monir Modaresinejad, Xiaojuan Yang, Mohammad A Mohammad Nezhady, Tang Zhu, Emmanuel Bajon, Xin Hou, Houda Tahiri, Pierre Hardy, José C Rivera, Pierre Lachapelle and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monir ModaresinejadProgram in Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Xiaojuan YangSchool of Optometry, Université de Montréal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; Departments of Ophthalmology and Neurology-Neurosurgery, Research Institute of the McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada.
Mohammad A Mohammad NezhadyDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; Program in Molecular Biology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada.
Tang ZhuDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Emmanuel BajonDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Xin HouDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Houda TahiriDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Pierre HardyDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
José C RiveraDepartment of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada.
Pierre LachapelleDepartments of Ophthalmology and Neurology-Neurosurgery, Research Institute of the McGill University Health Centre-Montreal Children's Hospital, Montreal, Quebec, Canada.
Sylvain ChemtobProgram in Biomedical Science, Faculty of Medicine, Université de Montreal, Montreal, Quebec, Canada; Department of Pediatrics, Ophthalmology and Pharmacology, Centre de Recherche du CHU Sainte-Justine, Montréal, Quebec, Canada; School of Optometry, Université de Montréal, Montreal, Quebec, Canada. Electronic address: sylvain.chemtob@umontreal.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The subretina, composed of the choroid and the retinal pigment epithelium (RPE), plays a critical role in proper vision. In addition to phagocytosis of photoreceptor debris, the RPE shuttles oxygen and nutrients to the neuroretina. For their own energy production, RPE cells mainly rely on lactate, a major by-product of glycolysis. Lactate, in turn, conveys most of its biological effects via the hydroxycarboxylic acid receptor 1 (HCAR1). Herein, the lactate-specific receptor, HCAR1, was found to be exclusively expressed in the RPE cells within the subretina, and Hcar1

Indexed as

ChoroidEndoplasmic Reticulum StressMice, KnockoutReceptors, G-Protein-CoupledAnimalsEukaryotic Initiation Factor-2MiceMice, Inbred C57BLPhosphorylationRetinal Pigment EpitheliumEukaryotic Initiation Factor-2Receptors, G-Protein-Coupled

Identifiers

PMID39332673
PMCPMC12179509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.