Evidence map›Paper›PMID 39332403›Full record

ArticleCurrent biology : CB2024

Ancient developmental genes underlie evolutionary novelties in walking fish.

Amy L Herbert, Corey A H Allard, Matthew J McCoy, Julia I Wucherpfennig, Stephanie P Krueger, Heidi I Chen, Allex N Gourlay, Kohle D Jackson, Lisa A Abbo, Scott H Bennett and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. The genomic origins and evolutionary path to a key innovation in the world's most venomous snakes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Evolution of sensory organs: Lessons from walking fish.Current opinion in neurobiology · 2026
    Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Amy L HerbertDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Corey A H AllardDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Matthew J McCoyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Julia I WucherpfennigDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stephanie P KruegerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Heidi I ChenDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Allex N GourlayRoger Williams University, Bristol, RI 02809, USA.
Kohle D JacksonDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lisa A AbboMarine Biological Laboratory, Woods Hole, MA 02543, USA.
Scott H BennettMarine Biological Laboratory, Woods Hole, MA 02543, USA.
Joshua D SearsRoger Williams University, Bristol, RI 02809, USA.
Andrew L RhyneRoger Williams University, Bristol, RI 02809, USA.
Nicholas W BellonoDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: nbellono@harvard.edu.
David M KingsleyHoward Hughes Medical Institute Stanford University School of Medicine, Stanford, CA 02543, USA. Electronic address: kingsley@stanford.edu.

Funding

Molecular Mechanisms of Integrative Signal TransductionR35GM142697 · NIGMS · HARVARD UNIVERSITY · PI Nicholas Bellono · 2021 to 2026
$2.6M
NIGMS NIH HHS R35 GM142697
6 · The paper itself

Abstract

A critical question in biology is how new traits evolve, but studying this in wild animals remains challenging. Here, we probe the genetic basis of trait gain in sea robin fish, which have evolved specialized leg-like appendages for locomotion and digging along the ocean floor. We use genome sequencing, transcriptional profiling, and interspecific hybrid analysis to explore the molecular and developmental basis of leg formation. We identified the ancient, conserved transcription factor tbx3a as a major determinant of sensory leg development. Genome editing confirms that tbx3a is required for normal leg formation in sea robins, and for formation of enlarged central nervous system lobes, sensory papillae, and adult digging behavior. Our study establishes sea robins as a model organism for studying the evolution of major trait gain and illustrates how ancient developmental control genes can underlie novel organ formation.

Indexed as

Biological EvolutionAnimalsExtremitiesFish ProteinsGene Expression Regulation, DevelopmentalGenes, DevelopmentalT-Box Domain ProteinsWalkingFish ProteinsT-Box Domain Proteinscis- and trans- regulatory changesevolutionary innovationgenomics and genome editinghybrids and species differencesleg-like appendageslimb and fin developmentsea robinsensory papillaetbx3 and Ulnar-mammary syndromewalking fish

Identifiers

PMID39332403
PMCPMC11552234

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.