Evidence map›Paper›PMID 39332400›Full record

ArticleCurrent biology : CB2024

Evolution of novel sensory organs in fish with legs.

Corey A H Allard, Amy L Herbert, Stephanie P Krueger, Qiaoyi Liang, Brittany L Walsh, Andrew L Rhyne, Allex N Gourlay, Agnese Seminara, Maude W Baldwin, David M Kingsley and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Evolution of sensory organs: Lessons from walking fish.Current opinion in neurobiology · 2026
    Review
  3. Peripheral mechanisms of tactile sensation in fish.Current opinion in neurobiology · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Evolution of Sensory Receptors.Annual review of cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Corey A H AllardDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Amy L HerbertDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Stephanie P KruegerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Qiaoyi LiangMax Planck Institute for Biological Intelligence, 82319 Seewiesen, Germany.
Brittany L WalshDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
Andrew L RhyneRoger Williams University, Bristol, RI 02809, USA.
Allex N GourlayRoger Williams University, Bristol, RI 02809, USA.
Agnese SeminaraDepartment of Civil, Chemical and Environmental Engineering, University of Genoa, 16145 Genoa, Italy.
Maude W BaldwinMax Planck Institute for Biological Intelligence, 82319 Seewiesen, Germany.
David M KingsleyDepartment of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kingsley@stanford.edu.
Nicholas W BellonoDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: nbellono@harvard.edu.

Funding

Molecular Mechanisms of Integrative Signal TransductionR35GM142697 · NIGMS · HARVARD UNIVERSITY · PI Nicholas Bellono · 2021 to 2026
$2.6M
Navigation with complex odor dynamics: computational principles and neural circuit implementation in miceR01DC018789 · NIDCD · UNIVERSITY OF WASHINGTON · PI GIRE, DAVID HENRY · 2020 to 2024
$1.8M
Howard Hughes Medical InstituteNIDCD NIH HHS R01 DC018789NIGMS NIH HHS R35 GM142697
6 · The paper itself

Abstract

How do animals evolve new traits? Sea robins are fish that possess specialized leg-like appendages used to "walk" along the sea floor. Here, we show that legs are bona fide sense organs that localize buried prey. Legs are covered in sensory papillae that receive dense innervation from touch-sensitive neurons, express non-canonical epithelial taste receptors, and mediate chemical sensitivity that drives predatory digging behavior. A combination of developmental analyses, crosses between species with and without papillae, and interspecies comparisons of sea robins from around the world demonstrate that papillae represent a key evolutionary innovation associated with behavioral niche expansion on the sea floor. These discoveries provide unique insight into how molecular-, cellular-, and tissue-scale adaptations integrate to produce novel organismic traits and behavior.

Indexed as

Biological EvolutionExtremitiesAnimalsPredatory BehaviorSense Organsbehavioral evolutionchemosensationcomparative biologyevolutionary innovationleg-like appendageslimb formationsea robinsensory papillaetaste receptorswalking fish

Identifiers

PMID39332400
PMCPMC11552235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.