ArticleUltrasonics sonochemistry2024
Ultrasound-assisted extraction of polyphenols from Phyllanthi Fructus: Comprehensive insights from extraction optimization and antioxidant activity.
Article in Ultrasonics sonochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- An integrated approach: green extraction technique optimization, mechanistic study, and bioactivity profiling of four flavonoids fromRSC advances · 2026Article
- A Review ofFoods (Basel, Switzerland) · 2026Review
- Ultrasound-assisted deep eutectic solvent extraction of polyphenols from Cornus officinalis: Optimization, mechanisms, and bioactivity.Ultrasonics sonochemistry · 2026Article
- Integration of ANN-GA optimization and multi-scale mechanistic analysis for ultrasound-assisted enzymatic extraction of flavonoids from Cortex Mori.Ultrasonics sonochemistry · 2026Article
- Exploration of the mechanism of Xinjiang Rosa laxa Retz.Fruit extract on IgA nephropathy by bioinformatics and machine learning methods.Bioresources and bioprocessing · 2026Article
- RSM- and ANN-Based Optimization of Bioactive Anthocyanin and Phenolic Compound Recovery fromAntioxidants (Basel, Switzerland) · 2026Article
- Ultrasound-Assisted Extraction of Yellow Peacock Flower (Antioxidants (Basel, Switzerland) · 2026Article
- Docynia delavayi (Franch.) Schneid polyphenols: Optimization of ultrasound-assisted extraction and bioactivity study.Ultrasonics sonochemistry · 2026Article
- Recovery of Bioactive Compounds from Pomegranate Seeds (Plants (Basel, Switzerland) · 2026Article
- Integrated in silico and in vitro evaluation of cocoa pod husk as potential anticancer agents against hepatocellular carcinoma.Molecular biology reports · 2026Article
- N-acetyl Cysteine Reduces Behavioral Disorders of the First and Second-generation Weaned Mice through the Modulation of TAC and the DNMT1 Gene Expression in the Hippocampus.Current pharmaceutical design · 2026Article
- Liposome-integrated ultrasound coupling subcritical water extraction for enhanced the efficiency and stability of Phyllanthus emblica polyphenols.Ultrasonics sonochemistry · 2026Article
- Direct vs indirect ultrasound-assisted extraction of phenolics from wild sumac (Rhus tripartita): Optimization by Response Surface Methodology (RSM) and LC-MS profiling.Ultrasonics sonochemistry · 2026Article
- Sustainable and integrated cascade valorization of the biomass generated by the invasive plantFrontiers in bioengineering and biotechnology · 2026Article
- Effect of ultrasound-assisted extraction combined with enzymatic pretreatment on bioactive compounds, antioxidant capacity and flavor characteristics of grape pulp extracts.Ultrasonics sonochemistry · 2025Article
- The ANFIS-RSM based multi-objective optimization and modelling of ultrasound-assisted extraction of polyphenols from jamun fruit (Syzygium cumini).Ultrasonics sonochemistry · 2025Article
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10 authors.
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Abstract
Phyllanthi Fructus (PF) is a valuable botanical resource with a long history of traditional use, known for potent antioxidant and anti-inflammatory effects attributed to its rich contents of bioactive compounds, particularly polyphenols. However, current extraction techniques limit the utilization of polyphenols from PF. This study aimed to achieve the maximum polyphenol yield and improve the antioxidant activity of PF extracts to promise PF's prospects for modern healthcare. Firstly, ultrasonic-assisted extraction (UAE) was employed to extract the polyphenols in PF and a combination of Plackett-Burman designs (PBD) and response surface methodology (RSM) was applied to optimize UAE's conditions. Next, cellular superoxide dismutase (SOD) and malondialdehyde (MDA) were used to assess the antioxidant activity of extracted polyphenols. Ultra-Performance Liquid Chromatography coupled with Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF MS) was utilized to characterize polyphenol components in the PF extracts. Finally, network pharmacology and molecular docking analysis were performed to screen the potential target proteins of polyphenols from PF. As a result, the optimized polyphenol yield was 213.49 mg/g, and the antioxidant activities, measured by ability of DPPH scavenging, ABTS+ scavenging, and FRAP were 76.95 %, 2.24 mmol/g, 2.34 mmol/g, respectively. PF extracts also showed good antioxidant capabilities at cellular level. 26 polyphenol components were identified in the PF extracts. Among these, ellagic acid, myricetin, and eriodictyol may exert antioxidant effects by interacting with AKT serine/threonine kinase 1 (AKT1). In conclusion, our study provides valuable insights into the optimizing PF extraction and underscores its potential applications in enhancing natural polyphenols extraction using UAE with a combination of PBD and RSM. These findings offer a promising avenue for the development and utilization of PF, and could serve as a reference for similar extraction processes in the future.
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