Evidence map›Paper›PMID 39331855›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Tumor Microenvironment Activated Cu Crosslinked Near-Infrared Sonosensitizers for Visualized Cuproptosis-Enhanced Sonodynamic Cancer Immunotherapy.

Jinyan Hu, Lang Yan, Zhi Cao, Bijiang Geng, Xiqian Cao, Bing Liu, Jiaming Guo, Jiangbo Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jinyan HuDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Lang YanDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Zhi CaoDepartment of Urology, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Bijiang GengDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Xiqian CaoDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Bing LiuDepartment of Urology, The Third Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Jiaming GuoDepartment of Radiation Medicine, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Jiangbo ZhuDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, Shanghai, 200433, China.

Funding

Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center SHDC12021118National Natural Science Foundation of China 31900890National Natural Science Foundation of China 82173649Natural Science Foundation of Shanghai Municipality 22ZR1477800Naval Medical University Youth Start-Up Fund 2023QN011Postdoctoral Fellowship Program of CPSF GZC20231526
6 · The paper itself

Abstract

Reactive oxygen species (ROS)-mediated sonodynamic therapy (SDT) holds increasing potential in treating deep-seated tumor owing to the high tissue-penetration depth. However, the inevitable accumulation of sonosensitizers in normal tissues not only make it difficult to realize the in situ SDT, but also induces sonodynamic effects in normal tissues. Herein, this work reports the passivation and selective activation strategies for the sonodynamic and near-infrared (NIR) imaging performances of an intelligent antitumor theranostic platform termed Cu-IR783 nanoparticles (NPs). Owing to the ruptured coordination bond between IR783 with Cu ions by responding to tumor microenvironment (TME), the selective activation of IR783 only occurred in tumor tissues to achieve the visualized in-situ SDT. The tumor-specific released Cu ions not only realized the cascade amplification of ROS generation through Cu

Indexed as

CopperImmunotherapyReactive Oxygen SpeciesTumor MicroenvironmentUltrasonic TherapyAnimalsCell Line, TumorDisease Models, AnimalHumansIndolesMiceNanoparticlesNeoplasms2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindoliumCopperIndolesReactive Oxygen Speciescuproptosisimmunotherapyintelligent nanoassembliestumor‐specific disassemblyvisualized sonodynamic therapy

Identifiers

PMID39331855
PMCPMC11578373

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.