Evidence map›Paper›PMID 39331716›Full record

ArticleScience advances2024

Pregnancy enhances antiviral immunity independent of type I IFN but dependent on IL-17-producing γδ

Julia Chronopoulos, Erwan Pernet, Kim A Tran, Toby K McGovern, Arina Morozan, Sadie Wang, Oscar Tsai, Kosuke Makita, Maziar Divangahi, James G Martin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. MX1Journal of translational medicine · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia ChronopoulosDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0009-0009-5843-7241
Erwan PernetMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-3595-4755
Kim A TranMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-0299-7417
Toby K McGovernMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-1721-3734
Arina MorozanDepartment of Medicine, McGill University, Montreal, Quebec, Canada.
Sadie WangDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0009-0002-0076-9349
Oscar TsaiMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Kosuke MakitaMeakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0002-8260-5761
Maziar DivangahiDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-1254-6110
James G MartinDepartment of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-7574-5363

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pregnancy is associated with profound changes in immunity. However, pregnancy-related respiratory immune adaptations in response to influenza infection and their impact on disease severity remain unclear. Here, we describe, in a preclinical model of mid-gestation pregnancy, a mechanism of enhanced host defense against influenza A virus (IAV) localized to the nasal cavity that limits viral replication and reduces the magnitude of intrapulmonary immune responses. Consequently, the pregnant mice show reduced pulmonary pathology and preserved airway function after IAV infection. The early restriction of viral replication is independent of type I interferon (IFN) but dependent on increased antimicrobial peptides (AMPs) driven by interleukin-17

Indexed as

Influenza A virusInterferon Type IInterleukin-17Nasal MucosaOrthomyxoviridae InfectionsAnimalsFemaleLungMicePregnancyReceptors, Antigen, T-Cell, gamma-deltaVirus ReplicationInterferon Type IInterleukin-17Receptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID39331716
PMCPMC11430450

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.