Evidence map›Paper›PMID 39331619›Full record

ReviewRheumatology (Oxford, England)2025

Vessel wall MRI in giant cell arteritis: standardized protocol and scoring approach developed by an international working group.

Rennie L Rhee, Girish Bathla, Ryan Rebello, Robert M Kurtz, Mats Junek, Kenneth J Warrington, Nader Khalidi, Peter A Merkel, Konstanze V Guggenberger, Madhura A Tamhankar and 2 more

Abstract readReview
In one paragraph

Review in Rheumatology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. [News on the imaging of large vessel vasculitis].Zeitschrift fur Rheumatologie · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rennie L RheeDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-4907-0304
Girish BathlaDivision of Neuroradiology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0003-3170-242X
Ryan RebelloDepartment of Diagnostic Imaging, St Joseph's Hospital, McMaster University, Hamilton, ON, Canada.
Robert M KurtzDivision of Neuroradiology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-1506-4141
Mats JunekDivision of Rheumatology, St Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-8416-3955
Kenneth J WarringtonDivision of Rheumatology, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0001-7708-2487
Nader KhalidiDivision of Rheumatology, St Joseph's Healthcare, McMaster University, Hamilton, ON, Canada.ORCID 0000-0002-8270-2617
Peter A MerkelDivision of Rheumatology, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-9284-7345
Konstanze V GuggenbergerDepartment of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Wuerzburg, Germany.ORCID 0000-0002-4840-0447
Madhura A TamhankarDivision of Neuro-Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, USA.
Thorsten A BleyDepartment of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, Wuerzburg, Germany.
Vasculitis Clinical Research Consortium

Funding

Establishing orbital and cranial vessel wall MRI enhancement as an imaging biomarker in giant cell arteritisR01AR084199 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI Rennie Rhee · 2025 to 2026
$543k
Career Development Bridge FundingDeutsche ForschungsgemeinschaftFoundation of Sarcoidosis ResearchNational Science FoundationNIAMS NIH HHS R01 AR084199Rheumatology Research Foundation
6 · The paper itself

Abstract

objectivesThere are an increasing number of centres performing research on high-resolution vessel wall magnetic resonance imaging (VW-MRI) in GCA. However, harmonized approaches to VW-MRI in GCA are lacking and are essential to performing multicentre studies. Using a data-driven, consensus-based approach, an international expert group developed a standardized MRI protocol and scoring system to advance multi-centred research in cranial GCA.

methodsA targeted literature review of VW-MRI in cranial GCA was conducted. A working group comprised of radiologists, rheumatologists and ophthalmologists with expertise in VW-MRI and GCA reviewed the results of the literature search, presented relevant data and images from their respective centres, and then reached consensus on recommendations related to key MRI structures, MRI sequences, scoring system and other important considerations.

resultsA total of 21 relevant articles were identified and reviewed. Based on published literature, structures to be evaluated on MRI were categorized based on anatomic location (extradural cranial, intradural cranial and orbits) and prioritization (core vs elective). Essential and elective sequences to comprehensively image cranial and orbital structures while minimizing scan time were determined along with scoring systems to grade contrast enhancement.

conclusionThis report describes a standardized approach to facilitate research of VW-MRI in cranial GCA that is the result of a multidisciplinary, international collaboration of experts in VW-MRI and/or GCA.

Indexed as

Giant Cell ArteritisMagnetic Resonance ImagingHumansGCAMRIrecommendation

Identifiers

PMID39331619
PMCPMC13396841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.