Evidence map›Paper›PMID 39331511›Full record

ArticleThe Journal of infectious diseases2025

Changes in the Lipidome Are Associated With Immune Activation and Subclinical Vascular Disease in Youth With Human Immunodeficiency Virus in Uganda.

Sahera Dirajlal-Fargo, Melica Nikahd, Kate Ailstock, Manjunath Manubolu, Victor Musiime, Cissy Kityo, Grace A McComsey, Nicholas T Funderburg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sahera Dirajlal-FargoPediatric Infectious Disease, Ann and Robert Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois.ORCID 0000-0001-9945-9062
Melica NikahdSchool of Health and Rehabilitation Sciences, Ohio State University, Columbus.
Kate AilstockSchool of Health and Rehabilitation Sciences, Ohio State University, Columbus.
Manjunath ManuboluSchool of Health and Rehabilitation Sciences, Ohio State University, Columbus.
Victor MusiimeDepartment of Pediatrics, Makerere University.
Cissy KityoJoint Clinical Research Center, Kampala, Uganda.
Grace A McComseyCase Western Reserve University School of Medicine, Cleveland, Ohio.
Nicholas T FunderburgSchool of Health and Rehabilitation Sciences, Ohio State University, Columbus.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
The role of Trained Immunity and Mitochondrial dysfunction on INnate immunity in children and adolescents aGing with PHIV (TIMING-PHIV)U01AI168630 · NIAID · OHIO STATE UNIVERSITY · PI Sahera Dirajlal-Fargo, Nicholas T. Funderburg · 2022 to 2026
$3.8M
Lipidome composition, immune activation and subclinical vascular disease in Adolescents with perinatally acquired HIV in UgandaR21HD106579 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI DIRAJLAL-FARGO, SAHERA · 2021 to 2022
$428k
Clinical and Translational Science Collaborative of Cleveland UL1TR002548)National Institute of Allergy and Infectious DiseasesNCATS NIH HHS UL1 TR002548NCATS NIH HHS UM1 TR004528NIAID NIH HHS U01 AI168630NICHD NIH HHS R21 HD106579(NIH)NIH HHSNIH Roadmap for Medical ResearchUniversity Hospitals Cleveland Medical Center Clinical Research Center
6 · The paper itself

Abstract

backgroundThis study examined the changes in the lipidome and associations with immune activation and cardiovascular disease (CVD) markers in youth with perinatally acquired human immunodeficiency virus (YPHIV).

methodsThe serum lipidome was measured in antiretroviral therapy (ART)-treated YPHIV (n = 100) and human immunodeficiency virus-uninfected children (n = 98) in Uganda. Plasma markers of systemic inflammation, monocyte activation, gut integrity, and T-cell activation, as well as common carotid artery intima media thickness and pulse wave velocity (PWV), were evaluated at baseline and 96 weeks.

resultsOverall, median age was 12 years, and 52% were females. Total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein were similar between the groups; however, the concentrations of ceramides, diacylglycerols, free fatty acids, lysophosphatidylcholines, and phosphatidylcholines were higher in YPHIV (P ≤ .03). Increases in phosphatidylethanolamine (16:0 and 18:0) correlated with increases in soluble CD163, oxidized LDL, C-reactive protein, intestinal fatty acid binding protein, and PWV in YPHIV (r ≥ 0.3).

conclusionsYPHIV successfully suppressed on ART have elevated lipid species that are associated with CVD, specifically palmitic acid (C16:0) and stearic acid (C18:0).

Indexed as

HIV InfectionsLipidomicsLipidsVascular DiseasesAdolescentBiomarkersCarotid Intima-Media ThicknessChildFemaleHumansMalePulse Wave AnalysisUgandaBiomarkersLipidscardiovascular diseaseimmune activationinflammationlipidsperinatally acquired HIV

Identifiers

PMID39331511
PMCPMC11841650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.