Evidence map›Paper›PMID 39331483›Full record

ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2024

Preliminary Evaluation of the Value of a Small-Molecule Probe Targeting DNMT1 in Detecting the Methylation of PAX1 in Cervical Cancer.

Baohua Yang, Qunxian Cheng, Xiaoqian Hong, Xiuxiang Zhu, Ziyin Xia, Wei Chen, Ling Xu

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Baohua YangDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.
Qunxian ChengDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.
Xiaoqian HongDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai, China.
Xiuxiang ZhuDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.
Ziyin XiaDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.
Wei ChenDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0000-6273-522X
Ling XuDepartment of Obstetrics and Gynecology, Minhang Hospital, Fudan University, Shanghai, China.

Funding

Special Project of Aging and Women & Children's Health Research in Shanghai 2020YJZX0208This research was funded by Special Project of Aging and Women & Children's Health Research in Shanghai, grant number 2020YJZX0208. 2020YJZX0208
6 · The paper itself

Abstract

backgroundTo investigate the screening value of a small-molecule probe to assess the methylation of PAX1 in cervical cancer. MATERIALS AND

methodsThe diagnostic threshold of the grayscale values for cervical lesions was assessed by plotting the Receiver Operating Characteristic (ROC) curve of subjects. Grayscale values were significantly different among the four groups (p < 0.05). Compared with the LSIL and cervicitis groups, a considerably higher grayscale value was found in the CA and high-grade squamous intraepithelial lesion (HSIL) groups (both p < 0.05).

resultsThe differential ROC curves of the grayscale values showed that the diagnostic Area Under Curve of the probe for cervicitis and low-grade squamous intraepithelial lesion (LSIL) was 0.8724 (95% CI = 0.7762-0.9685, p < 0.0001), for cervicitis and CA was 1.0000 (p < 0.0001), for the LSIL and HSIL was 0.5484 (95% CI = 0.3826-0.7142, p = 0.5755), and for the LSIL and CA was 0.7724 (95% CI = 0.6016-0.9432, p = 0.0138).

conclusionThe small molecular probe has certain application value in differentiating the type of cervical lesions and has better efficacy in distinguishing cervical inflammatory and precancerous lesions from carcinogenesis, but less efficacy in determining the type of precancerous lesions.

Indexed as

DNA (Cytosine-5-)-Methyltransferase 1DNA MethylationPaired Box Transcription FactorsUterine Cervical NeoplasmsAdultBiomarkers, TumorFemaleHumansMiddle AgedMolecular ProbesROC CurveSensitivity and SpecificityUterine Cervical DysplasiaUterine CervicitisBiomarkers, TumorDNA (Cytosine-5-)-Methyltransferase 1DNMT1 protein, humanMolecular ProbesPaired Box Transcription FactorsPAX1 transcription factorassessmentcervical cancermethylation markerscreening valuesmall molecule probe

Identifiers

PMID39331483
PMCPMC11430213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.