ArticleProceedings of the National Academy of Sciences of the United States of America2024
Mechanically adaptive and deployable intracortical probes enable long-term neural electrophysiological recordings.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Opto-Electrochemical Probes for In Vitro/In Vivo Analysis: Principles, Designs, and Applications.Biosensors · 2026Review
- Full-Stack Architectures for Intelligent Brain-Computer Interfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A comparative study assessing neural recording quality and inflammatory tissue response between stiff and flexible microelectrode arrays.Biomaterials · 2026Article
- Advances in neuroprostheses: interfaces, materials, and applications.Nano convergence · 2026Review
- Temporally Delayed Deployment of Photo-Responsive Liquid Crystal Polymer Networks Toward Neural Interfaces.Advanced healthcare materials · 2026Article
- Review of Recent Advances in Implantable Brain-Computer Interfaces for the Restoration of Motor Function in Patients With Paralysis.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Flexible Polymer-Based Electronics for Human Health Monitoring: A Safety-Level-Oriented Review of Materials and Applications.Nano-micro letters · 2026Review
- The Optically Guided and Pre-assembled Implantation Cranial Window Reveals Cortical Spatial Representations during Navigation.Research (Washington, D.C.) · 2026Article
- Cortical Response to Acute Implantation of the Utah Optrode Array in Macaque Cortex.Advanced healthcare materials · 2026Article
- Wearable Bioelectronics for Home-Based Monitoring and Treatment of Muscle Atrophy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Human-Centric, Three Dimensional Micro Light-Emitting Diodes for Cosmetic and Medical Phototherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multimodal integrated flexible neural probe forRSC advances · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Flexible intracortical probes offer important opportunities for stable neural interfaces by reducing chronic immune responses, but their advances usually come with challenges of difficult implantation and limited recording span. Here, we reported a mechanically adaptive and deployable intracortical probe, which features a foldable fishbone-like structural design with branching electrodes on a temperature-responsive shape memory polymer (SMP) substrate. Leveraging the temperature-triggered soft-rigid phase transition and shape memory characteristic of SMP, this probe design enables direct insertion into brain tissue with minimal footprint in a folded configuration while automatically softening to reduce mechanical mismatches with brain tissue and deploying electrodes to a broader recording span under physiological conditions. Experimental and numerical studies on the material softening and structural folding-deploying behaviors provide insights into the design, fabrication, and operation of the intracortical probes. The chronically implanted neural probe in the rat cortex demonstrates that the proposed neural probe can reliably detect and track individual units for months with stable impedance and signal amplitude during long-term implantation. The work provides a tool for stable neural activity recording and creates engineering opportunities in basic neuroscience and clinical applications.
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Registered trials
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