ArticleProceedings of the National Academy of Sciences of the United States of America2024
A geometric-tension-dynamics model of epithelial convergent extension.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- The role of geometry in morphogenesis.Development (Cambridge, England) · 2026Review
- Partial epithelial-to-mesenchymal transition mediates profound gap closure through growth and fluidization.bioRxiv : the preprint server for biology · 2026Article
- A Controlled in Silico Benchmark for GNN Prediction of Tissue Dynamics.Research square · 2026Article
- Article
- MultiCell: geometric learning in multicellular development.Nature methods · 2026Article
- Cell rearrangement progression along the apical-basal axis is linked with 3D epithelial tissue structure.PRX life · 2026Article
- Searching for physical principles of morphogenesis.Development (Cambridge, England) · 2025Review
- Quantifying convergent extension: Shih and Keller's quintessential work in developmental cell biology.Developmental biology · 2025Article
- Dynamical systems of fate and form in development.Seminars in cell & developmental biology · 2025Review
- Advances in mechanochemical modelling of vertebrate gastrulation.Biochemical Society transactions · 2025Article
- Basement membrane perforations guide anterior-posterior axis formation.Nature communications · 2025Article
- Blender tissue cartography: an intuitive tool for the analysis of dynamic 3D microscopy data.bioRxiv : the preprint server for biology · 2025Article
- Control of tissue flows and embryo geometry in avian gastrulation.Nature communications · 2025Article
- Inferring active and passive mechanical drivers of epithelial convergent extension.bioRxiv : the preprint server for biology · 2025Article
- Article
- Signatures of structural disorder in the developingPRX life · 2024Article
- The Geometric Basis of Epithelial Convergent Extension.bioRxiv : the preprint server for biology · 2024Article
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Abstract
Convergent extension of epithelial tissue is a key motif of animal morphogenesis. On a coarse scale, cell motion resembles laminar fluid flow; yet in contrast to a fluid, epithelial cells adhere to each other and maintain the tissue layer under actively generated internal tension. To resolve this apparent paradox, we formulate a model in which tissue flow in the tension-dominated regime occurs through adiabatic remodeling of force balance in the network of adherens junctions. We propose that the slow dynamics within the manifold of force-balanced configurations is driven by positive feedback on myosin-generated cytoskeletal tension. Shifting force balance within a tension network causes active cell rearrangements (T1 transitions) resulting in net tissue deformation oriented by initial tension anisotropy. Strikingly, we find that the total extent of tissue deformation depends on the initial cellular packing order. T1s degrade this order so that tissue flow is self-limiting. We explain these findings by showing that coordination of T1s depends on coherence in local tension configurations, quantified by a geometric order parameter in tension space. Our model reproduces the salient tissue- and cell-scale features of germ band elongation during
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