Interest in Oral Pre-exposure Prophylaxis Among Men Who Have Sex with Men and Transfeminine Persons in HPTN 075, a Multi-center HIV Prevention Study in Sub-Saharan Africa (2015-2017).
Joseph O Orinda, Victor Mudhune, Valarie Opollo, Calvin Mbeda, Ravindre Panchia, Erica Hamilton, Sufia Dadabhai, Doerieyah Reynolds, Theodorus G M Sandfort, HPTN 075 study team
Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Joseph O OrindaHIV Research Division, Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Victor MudhuneHIV Research Division, Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Valarie OpolloHIV Research Division, Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Calvin MbedaHIV Research Division, Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Ravindre PanchiaPerinatal HIV Research Unit, University of the Witwatersrand, Soweto, South Africa.
Erica HamiltonNetwork and Collaborative Research Division, FHI 360, Durham, NC, USA.
Sufia DadabhaiJohns Hopkins School of Public Health and Johns Hopkins Research Project, Blantyre, Malawi.
Doerieyah ReynoldsDesmond Tutu Health Foundation, Cape Town, South Africa.
Theodorus G M SandfortDepartment of Psychiatry, HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, Columbia University, 1051 Riverside Dive, Unit 15, New York, NY, USA. tgs2001@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-4986-1739
HPTN 075 study team
Funding
LOC: HIV Prevention Trials NetworkUM1AI068619 · NIAID · FAMILY HEALTH INTERNATIONAL · PI MYRON Scott COHEN, Sinead Delany-Moretlwe · 2011 to 2026
$779.5M
SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
LC: HIV Prevention Trials Network - Laboratory Support for the SARS-CoV-2 Seroprevalence Study (CoVPN 5002)UM1AI068613 · NIAID · JOHNS HOPKINS UNIVERSITY · PI SUSAN H ESHLEMAN, Mark A Marzinke · 2011 to 2026
$100.2M
The Statistics, Data Science, and Data Management (SDM) CoreP30MH043520 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI MILTON L WAINBERG · 2003 to 2026
$48.2M
The Malawi Clinical Trials UnitUM1AI069518 · NIAID · JOHNS HOPKINS UNIVERSITY · PI JACKY M JENNINGS, TAHA E TAHA · 2012 to 2026
$43.8M
In-depth Understanding of HIV Risk Behavior among Men Who Have Sex With Men in Sub-Saharan Africa: Secondary Analysis of HPTN 075 DataR21MH130217 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI SANDFORT, THEODORUS G.M. · 2022 to 2023
$455k
National Institute of Allergies and Infectious Diseases UM1AI068613National Institute of Allergies and Infectious Diseases UM1AI068617National Institute of Allergy and Infectious Diseases UM1AI068619NIAID NIH HHS UM1 AI068613NIAID NIH HHS UM1 AI068617NIAID NIH HHS UM1 AI068619NIAID NIH HHS UM1 AI069518NIMH NIH HHS P30 MH043520NIMH NIH HHS P30MH43520NIMH NIH HHS R21 MH130217NIMH NIH HHS R21MH130217
6 · The paper itself
Abstract
Use of oral pre-exposure prophylaxis (O-PrEP) for HIV prevention has not been fully utilized in sub-Saharan Africa, especially among key populations with high HIV incidence and prevalence, including men who have sex with men (MSM) and transgender women (TGW). We examined correlates of interest in O-PrEP among participants in the HIV Prevention Trials Network (HPTN) Study 075, a prospective cohort study, conducted between 2015 and 2017, across 4 sites in Kenya, Malawi, and South Africa. The study included persons assigned male sex at birth, between 18 and 44 years of age, who reported anal intercourse with a man in the past 3 months. Interest in O-PrEP and potential correlates were assessed among 297 participants who were HIV negative. 52% of the participants reported being aware of PrEP and 73% indicated interest in PrEP once informed about it. PrEP interest was not significantly associated with any of the surveyed demographic or psychosocial variables except study site. Our findings suggest a broad and general interest in O-PrEP among MSM and TGW in sub-Saharan Africa, despite relatively low awareness. While the situation around PrEP will have changed in the included countries, major questions about successful implementation still need to be addressed.
Indexed as
Anti-HIV AgentsHIV InfectionsPre-Exposure ProphylaxisSexual and Gender MinoritiesTransgender PersonsAdministration, OralAdolescentAdultAfrica South of the SaharaFemaleHealth Knowledge, Attitudes, PracticeHomosexuality, MaleHumansMaleProspective StudiesYoung AdultAnti-HIV AgentsMen who have sex with menPre-exposure prophylaxis (PrEP)Sub-Saharan AfricaTransfeminine persons
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Interest in Oral Pre-exposure Prophylaxis Among Men Who Have Sex with Men and Transfeminine Persons in HPTN 075, a Multi-center HIV Prevention Study in Sub-Saharan Africa (2015-2017). · full record | OpenQuestion