Evidence map›Paper›PMID 39330834›Full record

ArticleToxins2024

Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model.

Rose H Dicovitsky, Jill T Schappa, Ashley J Schulte, Haeree P Lang, Ellen Kuerbitz, Sarah Roberts, Taylor A DePauw, Mitzi Lewellen, Amber L Winter, Kathy Stuebner and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Rose H DicovitskyDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Jill T SchappaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Ashley J SchulteDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Haeree P LangDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Ellen KuerbitzDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Sarah RobertsDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Taylor A DePauwDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0009-0006-5235-753X
Mitzi LewellenDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Amber L WinterAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Kathy StuebnerAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Michelle BuettnerAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Kelly ReidAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Kelly BergsrudAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Sara PrachtAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Andrea ChehadehAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Caitlin FeiockDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
M Gerard O'SullivanAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Tim CarlsonDepartment of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Alexandra R ArmstrongDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-8498-2843
Danielle MeritetDepartment of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.ORCID 0000-0003-4445-7291
Michael S HensonDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Brenda J WeigelAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.
Jaime F ModianoDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0001-6398-7648
Antonella BorgattiDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0003-1939-0611
Daniel A ValleraAnimal Cancer Care and Research Program, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0003-4587-3238

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
Veterinary Summer Scholars in Comparative MedicineT35OD011118 · OD · UNIVERSITY OF MINNESOTA · PI EDWARD E PATTERSON · 2012 to 2026
$601k
NCI NIH HHS P30 CA077598NIH HHS 1K01TW171420-23A1NIH HHS T35 OD011118
6 · The paper itself

Abstract

EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established. Recombinant eBAT was created by combining cytokines EGF and uPA on the same single-chain molecule with truncated

Indexed as

ErbB ReceptorsReceptors, Urokinase Plasminogen ActivatorAnimalsAntineoplastic AgentsDogsEpidermal Growth FactorFemaleLigandsMaleMiceMice, Inbred C57BLMice, KnockoutSarcomaUrokinase-Type Plasminogen ActivatorAntineoplastic AgentsEpidermal Growth FactorErbB ReceptorsLigandsReceptors, Urokinase Plasminogen ActivatorUrokinase-Type Plasminogen Activatorimmunotoxinpharmacologysarcomatargeted therapytoxicity

Identifiers

PMID39330834
PMCPMC11436214

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.