Evidence map›Paper›PMID 39330820›Full record

ArticleVeterinary sciences2024

Predictive Neuromarker Patterns for Calcification Metaplasia in Early Tendon Healing.

Melisa Faydaver, Valeria Festinese, Oriana Di Giacinto, Mohammad El Khatib, Marcello Raspa, Ferdinando Scavizzi, Fabrizio Bonaventura, Valentina Mastrorilli, Paolo Berardinelli, Barbara Barboni and 1 more

Abstract read
In one paragraph

Article in Veterinary sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Melisa FaydaverUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0001-6651-4854
Valeria FestineseUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Oriana Di GiacintoUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Mohammad El KhatibUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-0976-2522
Marcello RaspaNational Research Council (CNR), Campus International Development (EMMA-INFRAFRONTIER-IMPC), Institute of Biochemistry and Cellular Biology (IBBC), 00015 Monterotondo Scalo, Italy.
Ferdinando ScavizziNational Research Council (CNR), Campus International Development (EMMA-INFRAFRONTIER-IMPC), Institute of Biochemistry and Cellular Biology (IBBC), 00015 Monterotondo Scalo, Italy.
Fabrizio BonaventuraNational Research Council (CNR), Campus International Development (EMMA-INFRAFRONTIER-IMPC), Institute of Biochemistry and Cellular Biology (IBBC), 00015 Monterotondo Scalo, Italy.
Valentina MastrorilliPlaisant S.r.l., 00128 Rome, Italy.
Paolo BerardinelliUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.
Barbara BarboniUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-0231-8066
Valentina RussoUnit of Basic and Applied Biosciences, Department of Biosciences, Agro-Food and Environmental Technologies, University of Teramo, 64100 Teramo, Italy.ORCID 0000-0003-4368-2534

Funding

Innovation, digitalization and sustainability for the diffused economy in Central Italy - VITALITY. ECS00000041Perspective for Future Innovation in Tendon Repair H2020MSCA-ITN-EJD-P4 FIT 955685
6 · The paper itself

Abstract

Unsuccessful tendon healing leads to fibrosis and occasionally calcification. In these metaplastic drifts, the mouse AT preclinical injury model represents a robust experimental setting for studying tendon calcifications. Previously, calcium deposits were found in about 30% of tendons after 28 days post-injury. Although a neuromediated healing process has previously been documented, the expression patterns of NF200, NGF, NPY, GAL, and CGRP in mouse AT and their roles in metaplastic calcific repair remain to be explored. This study included a spatiotemporal analysis of these neuromarkers during the inflammatory phase (7 days p.i.) and the proliferative/early-remodelling phase (28 days p.i.). While the inflammatory phase is characterised by NF200 and CGRP upregulation, in the 28 days p.i., the non-calcified tendons (

Indexed as

Achilles tendonanimal modelscalcificationchondrocyte-like cellsmetaplasiamiceneuromarkers

Identifiers

PMID39330820
PMCPMC11435825

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.