Evidence map›Paper›PMID 39330818›Full record

ArticleVeterinary sciences2024

Oral Fecal Microbiota Transplantation in Dogs with Tylosin-Responsive Enteropathy-A Proof-of-Concept Study.

Mohsen Hanifeh, Elisa Scarsella, Connie A Rojas, Holly H Ganz, Mirja Huhtinen, Tarmo Laine, Thomas Spillmann

Abstract read
In one paragraph

Article in Veterinary sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohsen HanifehDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00790 Helsinki, Finland.
Elisa ScarsellaAnimalBiome, 400 29th Street, Suite 101, Oakland, CA 94609, USA.ORCID 0000-0002-1463-4608
Connie A RojasAnimalBiome, 400 29th Street, Suite 101, Oakland, CA 94609, USA.ORCID 0000-0002-6097-8970
Holly H GanzAnimalBiome, 400 29th Street, Suite 101, Oakland, CA 94609, USA.
Mirja HuhtinenOrion Corporation, R&D, 02200 Espoo, Finland.
Tarmo LaineOrion Corporation, R&D, 02200 Espoo, Finland.
Thomas SpillmannDepartment of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, 00790 Helsinki, Finland.ORCID 0000-0002-0176-7428

Funding

Orion Corporation (Finland) V3130001
6 · The paper itself

Abstract

A clinical trial was conducted to evaluate the effect of fecal microbiota transplantation (FMT) on the canine chronic enteropathy clinical activity index (CCECAI), fecal consistency, and microbiome of dogs with tylosin-responsive enteropathy (TRE). The trial consisted of four phases: (1) screening with discontinuation of tylosin for 4 weeks, (2) inclusion with re-introduction of tylosin for 3-7 days, (3) treatment with FMT/placebo for 4 weeks, and (4) post-treatment with follow-up for 4 weeks after treatment cessation. The study found that the treatment efficacy of FMT (71.4%) was slightly higher than that of placebo (50%), but this difference was not statistically significant due to underpowering. The most abundant bacterial species detected in the fecal microbiomes of dogs with TRE before FMT or placebo treatment were

Indexed as

chronic enteropathydogsfecal microbiomefecal microbiota transplantmicrobiome diversityplacebotylosin-responsive enteropathy

Identifiers

PMID39330818
PMCPMC11435887

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.