Evidence map›Paper›PMID 39330666›Full record

ArticleNanomaterials (Basel, Switzerland)2024

Targeting Myeloid-Derived Suppressor Cells via Dual-Antibody Fluorescent Nanodiamond Conjugate.

Colin D Angell, Gabriella Lapurga, Steven H Sun, Courtney Johnson, Himanshu Savardekar, Isaac V Rampersaud, Charles Fletcher, David Albertson, Casey Ren, Lorena P Suarez-Kelly and 2 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Colin D AngellThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-5014-0170
Gabriella LapurgaThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Steven H SunThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0002-0173-3762
Courtney JohnsonThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Himanshu SavardekarThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.
Isaac V RampersaudColumbus NanoWorks, Inc., 1507 Chambers Road, Columbus, OH 43212, USA.
Charles FletcherColumbus NanoWorks, Inc., 1507 Chambers Road, Columbus, OH 43212, USA.ORCID 0009-0008-1491-2381
David AlbertsonColumbus NanoWorks, Inc., 1507 Chambers Road, Columbus, OH 43212, USA.
Casey RenThe Arthur G. James Comprehensive Cancer Center and Solove Research Institute, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-6378-746X
Lorena P Suarez-KellyDepartment of Surgery, University of Nevada, Las Vegas, NV 89102, USA.
Arfaan A RampersaudColumbus NanoWorks, Inc., 1507 Chambers Road, Columbus, OH 43212, USA.
William E CarsonDepartment of Surgery, The Ohio State University, Columbus, OH 43210, USA.ORCID 0000-0001-7024-7533

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
TWO SIGNAL REQUIREMENT FOR NATURAL KILLER IMMUNITYP01CA095426 · NCI · OHIO STATE UNIVERSITY · PI MUTHUSAMY, NATARAJAN · 2002 to 2016
$29.6M
UM1 Supplement for Early Therapeutic Trials with Phase 2 IntentUM1CA186712 · NCI · OHIO STATE UNIVERSITY · PI SUSANNE M ARNOLD, WILLIAM E. CARSON · 2014 to 2026
$19.3M
Tumor ImmunologyT32CA090223 · NCI · OHIO STATE UNIVERSITY · PI CARSON, WILLIAM E. · 2002 to 2023
$4.1M
Topic 396 - Imaging for Cancer Immunotherapies-Moonshot75N91019C00014 · NCI · COLUMBUS NANOWORKS, INC. · PI RAMPERSAUD, ARFAAN · 2019 to 2019
$300k
NCI NIH HHS 75N91019C00014NCI NIH HHS P01 CA095426NCI NIH HHS P30 CA016058NCI NIH HHS T32 CA090223NCI NIH HHS UM1 CA186712NHLBI NIH HHS HHSN268201300031CNIH HHS HHSN268201300031CNIH HHS P01 CA95426NIH HHS P30 CA016058NIH HHS T32 5T32CA090223NIH HHS UM1 CA186712
6 · The paper itself

Abstract

Fluorescent nanodiamonds (FNDs) are carbon-based nanomaterials that emit bright, photostable fluorescence and exhibit a modifiable surface chemistry. Myeloid-derived suppressor cells (MDSCs) are an immunosuppressive cell population known to expand in cancer patients and contribute to worse patient outcomes. To target MDSC, glycidol-coated FND were conjugated with antibodies against the murine MDSC markers, CD11b and GR1 (dual-Ab FND). In vitro, dual-Ab FND uptake by murine MDSC was significantly higher than IgG-coated FND (94.7% vs. 69.0%,

Indexed as

antibody conjugationfluorescent nanodiamondsMDSC

Identifiers

PMID39330666
PMCPMC11434946

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.