Evidence map›Paper›PMID 39330559›Full record

ArticleToxics2024

Assessing Receptor Activation in 2D and 3D Cultured Hepatocytes: Responses to a Single Compound and a Complex Mixture.

Laiba Jamshed, Shanza Jamshed, Richard A Frank, L Mark Hewitt, Philippe J Thomas, Alison C Holloway

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Beyond monolayers: a comparative analysis of 2D cell cultures and 3DFrontiers in bioengineering and biotechnology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Laiba JamshedDepartment of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0002-8510-3740
Shanza JamshedDepartment of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.
Richard A FrankWater Science and Technology Directorate, Environment and Climate Change Canada, Burlington, ON L7S 1A1, Canada.
L Mark HewittWater Science and Technology Directorate, Environment and Climate Change Canada, Burlington, ON L7S 1A1, Canada.ORCID 0000-0002-3683-562X
Philippe J ThomasEnvironment and Climate Change Canada, National Wildlife Research Centre, Ottawa, ON K1S 5B6, Canada.
Alison C HollowayDepartment of Obstetrics and Gynecology, McMaster University, Hamilton, ON L8S 4L8, Canada.ORCID 0000-0002-4343-5325

Funding

Chemical Management Plan 2022Natural Sciences and Engineering Research Council RGPIN-2020-06358
6 · The paper itself

Abstract

Responding to global standards and legislative updates in Canada, including Bill S-5 (2023), toxicity testing is shifting towards more ethical,

Indexed as

apoptosiscell culturedexamethasonemonolayernaphthenic acidsreceptor activationspheroidsthree-dimensional (3D)two-dimensional (2D)

Identifiers

PMID39330559
PMCPMC11436198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.