Evidence map›Paper›PMID 39330506›Full record

ArticleMetabolites2024

Identification of Plasma Metabolomic Biomarkers of Juvenile Idiopathic Arthritis.

Amar Kumar, Joshua Tatarian, Valentina Shakhnovich, Rachel L Chevalier, Marc Sudman, Daniel J Lovell, Susan D Thompson, Mara L Becker, Ryan S Funk

Abstract read
In one paragraph

Article in Metabolites, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amar KumarCenter for Computational Biology, University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0001-8513-673X
Joshua TatarianUniversity of Kansas School of Medicine, Kansas City, KS 66160, USA.ORCID 0000-0002-1947-6194
Valentina ShakhnovichIronwood Pharmaceuticals, Boston, MA 02110, USA.
Rachel L ChevalierUniversity of Missouri-Kansas City School of Medicine & Children's Mercy Kansas City, Kansas City, MO 64108, USA.ORCID 0000-0001-7628-6007
Marc SudmanCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Daniel J LovellCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.ORCID 0000-0003-1604-0130
Susan D ThompsonCincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Mara L BeckerDivision of Rheumatology, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0009-0008-1088-2015
Ryan S FunkCenter for Computational Biology, University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0002-3834-4672

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Diane E Mahoney · 2019 to 2026
$21.5M
Tissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7M
Institutional Career Development CoreKL2TR002367 · NCATS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATTHEW W MOSCONI, NICOLE L NOLLEN · 2017 to 2026
$7.3M
Identifying Pharmacogenomic Predictors of Methotrexate Response and Metabolite Biotransformation in JIAR01HD089928 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI BECKER, MARA LEIGH, THOMPSON, SUSAN D · 2017 to 2021
$2.8M
NCATS NIH HHS KL2 TR002367NIAMS NIH HHS P30 AR070549NICHD NIH HHS R01 HD089928NIGMS NIH HHS P20 GM130423University of Kansas Clinical and Translational Science Institute, Kansas Institute of Precision Medicine Centers of Biomedical Research Excellence KL2TR002367, P20GM130423
6 · The paper itself

Abstract

Identification of disease and therapeutic biomarkers remains a significant challenge in the early diagnosis and effective treatment of juvenile idiopathic arthritis (JIA). In this study, plasma metabolomic profiling was conducted to identify disease-related metabolic biomarkers associated with JIA. Plasma samples from treatment-naïve JIA patients and non-JIA reference patients underwent global metabolomic profiling across discovery (60 JIA, 60 non-JIA) and replication (49 JIA, 38 non-JIA) cohorts. Univariate analysis identified significant metabolites (

Indexed as

autoimmune diseasebiomarkersdisease-modifying antirheumatic drugsjuvenile idiopathic arthritismetabolomics

Identifiers

PMID39330506
PMCPMC11434325

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.