Evidence map›Paper›PMID 39330414›Full record

ArticleJournal of fungi (Basel, Switzerland)2024

Central Nervous System Fungal Diseases in Children with Malignancies: A 16-Year Study from the Infection Working Group of the Hellenic Society of Pediatric Hematology Oncology.

Loizos Petrikkos, Maria Kourti, Kondylia Antoniadi, Tatiana-Sultana Tziola, Angeliki-Eleni Sfetsiori, Vasiliki Antari, Sofia Savoukidou, Georgia Avgerinou, Maria Filippidou, Eugenia Papakonstantinou and 7 more

Abstract read
In one paragraph

Article in Journal of fungi (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Loizos PetrikkosDepartment of Pediatric Hematology-Oncology (T.A.O.), "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-8313-9141
Maria KourtiInfectious Diseases Unit, 3rd Department of Pediatrics, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.ORCID 0000-0001-5566-9295
Kondylia AntoniadiDepartment of Pediatric Hematology-Oncology (T.A.O.), "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Tatiana-Sultana TziolaPediatric Hematology-Oncology Unit, 1st Pediatric Department, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Angeliki-Eleni SfetsioriOncology Department, "P & A Kyriakou" Children's Hospital, 11527 Athens, Greece.
Vasiliki AntariChildren & Adolescent Hematology-Oncology Unit, Second Department of Pediatrics, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Sofia SavoukidouDepartment of Pediatric Oncology, Hippokration General Hospital, 54642 Thessaloniki, Greece.
Georgia AvgerinouPediatric Hematology-Oncology Unit, 1st Pediatric Department, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Maria FilippidouPediatric Hematology-Oncology Unit, 1st Pediatric Department, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Eugenia PapakonstantinouDepartment of Pediatric Oncology, Hippokration General Hospital, 54642 Thessaloniki, Greece.ORCID 0000-0001-5620-7885
Sophia PolychronopoulouDepartment of Pediatric Hematology-Oncology (T.A.O.), "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.
Emmanuel HatzipantelisChildren & Adolescent Hematology-Oncology Unit, Second Department of Pediatrics, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-7535-2970
Dimitrios DoganisOncology Department, "P & A Kyriakou" Children's Hospital, 11527 Athens, Greece.
Antonios KattamisPediatric Hematology-Oncology Unit, 1st Pediatric Department, "Aghia Sophia" Children's Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.ORCID 0000-0002-5178-0655
Vassilios PapadakisDepartment of Pediatric Hematology-Oncology (T.A.O.), "Aghia Sophia" Children's Hospital, 11527 Athens, Greece.ORCID 0000-0002-1821-7799
Emmanuel RoilidesInfectious Diseases Unit, 3rd Department of Pediatrics, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.ORCID 0000-0002-0202-364X
Athanasios TragiannidisChildren & Adolescent Hematology-Oncology Unit, Second Department of Pediatrics, Hippokration General Hospital, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0003-4294-2605

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We analyzed data on pediatric invasive fungal diseases of the central nervous system (CNS-IFDs) reported by five of a total of eight Pediatric Hematology-Oncology Departments in Greece for 16 years (2007-2022). A total of twelve patients (11 boys, median age: 9.5 years, range: 2-16) were reported suffering from CNS-IFDs. The underlying malignancy was acute lymphoblastic leukemia in 9/12 and acute myeloid leukemia, Ewing sarcoma, and rhabdomyosarcoma in one each. Eleven patients presented with CNS-related symptoms (i.e., seizures, headache, cerebral palsy, ataxia, hallucination, seizures, blurred vision, amaurosis). All patients had pathological MRI findings. Multifocal fungal disease was observed in 6/12 patients. Nine proven and three probable CNS-IFD cases were diagnosed. Causative pathogens in proven cases were

Indexed as

brain abscesscentral nervous systemchildreninvasive fungal infectionmalignanciesoutcome

Identifiers

PMID39330414
PMCPMC11433548

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.