ArticleGels (Basel, Switzerland)2024
A Novel Biomineralized Collagen Liquid Crystal Hydrogel Possessing Bone-like Nanostructures by Complete In Vitro Fabrication.
Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The microstructure of bone consists of nano-hydroxyapatite (nano-HA) crystals aligned within the interspaces of collagen fibrils. To emulate this unique microstructure of bone, this work applied two biomimetic techniques to obtain bone-like microstructures in vitro, that is, combining the construction of collagen liquid crystal hydrogel (CLCH) with the application of a polymer-induced liquid precursor (PILP) mineralization process. Upon the elevation of pH, the collagen macromolecules within the collagen liquid crystal (CLC) were activated to self-assemble into CLCH, whose fibrils packed into a long and dense fiber bundle in high orientation, emulating the dense-packed matrix of bone. We demonstrated that the fibrillar mineralization of CLCH, leading to a bone-like nanostructured inorganic material part, can be achieved using the PILP crystallization process to pre-mineralize the dense collagen substrates of CLCH with CaCO
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