Evidence map›Paper›PMID 39329818›Full record

ReviewBiosensors2024

Recent Electrochemical Advancements for Liquid-Biopsy Nucleic Acid Detection for Point-of-Care Prostate Cancer Diagnostics and Prognostics.

Joseph Broomfield, Melpomeni Kalofonou, Charlotte L Bevan, Pantelis Georgiou

Abstract readReview
In one paragraph

Review in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Joseph BroomfieldCentre for BioInspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-6872-322X
Melpomeni KalofonouCentre for BioInspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0001-8299-4106
Charlotte L BevanImperial Centre for Translational and Experimental Medicine, Department of Surgery and Cancer, Imperial College London, London W12 0NN, UK.ORCID 0000-0002-7533-0552
Pantelis GeorgiouCentre for BioInspired Technology, Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-2476-3857

Funding

Cancer Research UK C24523
6 · The paper itself

Abstract

Current diagnostic and prognostic tests for prostate cancer require specialised laboratories and have low specificity for prostate cancer detection. As such, recent advancements in electrochemical devices for point of care (PoC) prostate cancer detection have seen significant interest. Liquid-biopsy detection of relevant circulating and exosomal nucleic acid markers presents the potential for minimally invasive testing. In combination, electrochemical devices and circulating DNA and RNA detection present an innovative approach for novel prostate cancer diagnostics, potentially directly within the clinic. Recent research in electrochemical impedance spectroscopy, voltammetry, chronoamperometry and potentiometric sensing using field-effect transistors will be discussed. Evaluation of the PoC relevance of these techniques and their fulfilment of the WHO's REASSURED criteria for medical diagnostics is described. Further areas for exploration within electrochemical PoC testing and progression to clinical implementation for prostate cancer are assessed.

Indexed as

Electrochemical TechniquesPoint-of-Care SystemsProstatic NeoplasmsBiomarkers, TumorBiosensing TechniquesHumansLiquid BiopsyMaleNucleic AcidsPrognosisBiomarkers, TumorNucleic AcidschronoamperometryEISelectrochemical devicesfield-effect transistorsISFETnucleic acidspoint of careprostate cancervoltammetry

Identifiers

PMID39329818
PMCPMC11430765

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.