ArticleBiosensors2024
All-Dielectric Metasurface-Based Terahertz Molecular Fingerprint Sensor for Trace Cinnamoylglycine Detection.
Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Multifunctional plasmonic optical nanosensor based on ring resonator supercells for early pregnancy diagnosis using urine samples.Scientific reports · 2026Article
- All-LCP Terahertz Metasensor with Dual Quasi-BIC Resonances for Dual-Range Refractive Index Sensing.Biosensors · 2026Article
- Recent Advances in Metasurfaces: From THz Biosensing to Microwave Wireless Communications.Research (Washington, D.C.) · 2025Review
- Multi-Degree-of-Freedom Stretchable Metasurface Terahertz Sensor for Trace Cinnamoylglycine Detection.Biosensors · 2024Article
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Authors and funding
4 authors.
Funding
Abstract
Terahertz (THZ) spectroscopy has emerged as a superior label-free sensing technology in the detection, identification, and quantification of biomolecules in various biological samples. However, the limitations in identification and discrimination sensitivity of current methods impede the wider adoption of this technology. In this article, a meticulously designed metasurface is proposed for molecular fingerprint enhancement, consisting of a periodic array of lithium tantalate triangular prism tetramers arranged in a square quartz lattice. The physical mechanism is explained by the finite-difference time-domain (FDTD) method. The metasurface achieves a high quality factor (Q-factor) of 231 and demonstrates excellent THz sensing capabilities with a figure of merit (FoM) of 609. By varying the incident angle of the THz wave, the molecular fingerprint signal is strengthened, enabling the highly sensitive detection of trace amounts of analyte. Consequently, cinnamoylglycine can be detected with a sensitivity limit as low as 1.23 μg·cm-2. This study offers critical insights into the advanced application of THz waves in biomedicine, particularly for the detection of urinary biomarkers in various diseases, including gestational diabetes mellitus (GDM).
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