Evidence map›Paper›PMID 39329766›Full record

ArticleCells2024

Isolation of Functional Human MCT Transporters in

Hajira Ahmed Hotiana, Karl Patric Nordlin, Kamil Gotfryd, Per Amstrup Pedersen, Pontus Gourdon

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hajira Ahmed HotianaDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200 Copenhagen N, Denmark.
Karl Patric NordlinDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200 Copenhagen N, Denmark.
Kamil GotfrydDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200 Copenhagen N, Denmark.ORCID 0000-0002-0299-0779
Per Amstrup PedersenDepartment of Biology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen OE, Denmark.ORCID 0000-0001-8648-9748
Pontus GourdonDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200 Copenhagen N, Denmark.ORCID 0000-0002-8631-3539

Funding

Augustinus Foundation 16-1992Carlsberg Foundation CF15-0542Carlsberg Foundation CF21-0647Crafoord Foundation 20170818Crafoordska Stiftelsen 20180652Crafoordska Stiftelsen 20200739Crafoordska Stiftelsen 20220905Danmarks Frie Forskningsfond 3101-00303Danmarks Frie Forskningsfond 6108-00479Danmarks Frie Forskningsfond 8022-00368Danmarks Frie Forskningsfond 9039-00273Hartmann Fonden A29519Knut and Alice Wallenberg Foundation 2020.0194Lundbeck Foundation R313-2019-774Lundbeck Foundation R346-2020-2019Novo Nordisk Foundation 0078574Swedish Research Council 2016-04474Swedish Research Council 2022-01315
6 · The paper itself

Abstract

Human monocarboxylate transporters (hMCTs) belong to the solute carrier 16 (SLC16) family of proteins and are responsible for the bi-directional transport of various metabolites, including monocarboxylates, hormones, and aromatic amino acids. Hence, the metabolic role of hMCTs is undisputable, as they are directly involved in providing nutrients for oxidation and gluconeogenesis as well as participate in circulation of iodothyronines. However, due to the difficulty in obtaining suitable amounts of stable hMCT samples, the structural information available for these transporters is limited, hindering the development of effective therapeutics. Here we provide a straightforward, cost-effective strategy for the overproduction of hMCTs using a whole-cell

Indexed as

Monocarboxylic Acid TransportersSaccharomyces cerevisiaeHumansSymportersMonocarboxylic Acid TransportersSymportersaromatic amino acid transportershuman metabolismhuman monocarboxylate transporters (hMCTs)membrane proteinsoverproductionproduction platformprotein purificationSaccharomyces cerevisiaesolute carrier 16 (SLC16) familyyeast

Identifiers

PMID39329766
PMCPMC11430032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.