Evidence map›Paper›PMID 39329762›Full record

ArticleCells2024

The Effects of the Pneumonia Lung Microenvironment on MSC Function.

Lanzhi Liu, Juan Fandiño, Sean D McCarthy, Claire H Masterson, Ignacio Sallent, Shanshan Du, Abigail Warren, John G Laffey, Daniel O'Toole

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lanzhi LiuCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
Juan FandiñoCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
Sean D McCarthyCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
Claire H MastersonCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.ORCID 0000-0002-9863-5324
Ignacio SallentCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
Shanshan DuCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
Abigail WarrenCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.
John G LaffeyCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.ORCID 0000-0002-1246-9573
Daniel O'TooleCÚRAM Institute for Medical Devices, University of Galway, H91 W2TY Galway, Ireland.

Funding

Chinese Scholarship Council xxxxScience Foundation Ireland 13/RC/2073
6 · The paper itself

Abstract

backgroundDespite promise in preclinical models of acute respiratory distress syndrome (ARDS), mesenchymal stem cells (MSC) have failed to translate to therapeutic benefit in clinical trials. The MSC is a live cell medicine and interacts with the patient's disease state. Here, we explored this interaction, seeking to devise strategies to enhance MSC therapeutic function.

methodsHuman bone-marrow-derived MSCs were exposed to lung homogenate from healthy and

resultsThe ARDS model showed reduced arterial oxygenation, decreased lung compliance and an inflammatory microenvironment compared to controls. MSCs underwent more apoptosis after stimulation by lung homogenate from controls compared to

conclusionsThese findings suggest that the ARDS microenvironment plays an important role in the MSC's therapeutic mechanism of action, and changes can inform strategies to modulate MSC-based cell therapy for ARDS.

Indexed as

Cellular MicroenvironmentLungMesenchymal Stem CellsAnimalsApoptosisCell ProliferationCytokinesDisease Models, AnimalEscherichia coliHumansMaleMesenchymal Stem Cell TransplantationPneumoniaRatsRats, Sprague-DawleyRespiratory Distress SyndromeCytokinesinflammationlung microenvironmentmesenchymal stem cell (MSC)

Identifiers

PMID39329762
PMCPMC11430541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.