Evidence map›Paper›PMID 39329755›Full record

ArticleCells2024

α-Parvin Expression in Breast Cancer Tissues: Correlation with Clinical Parameters and Prognostic Significance.

Midori Takeda, Hiroaki Ito, Keisuke Kitahata, Sota Sato, Akira Nishide, Kanae Gamo, Shunsuke Managi, Tohru Tezuka, Akihiko Yoshizawa, Minsoo Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Midori TakedaLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.ORCID 0000-0002-8256-2386
Hiroaki ItoDepartment of Diagnostic Pathology, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto-shi 606-8507, Kyoto, Japan.ORCID 0000-0002-9573-778X
Keisuke KitahataLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.
Sota SatoLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.
Akira NishideLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.
Kanae GamoFIMECS, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa-shi 251-0012, Kanagawa, Japan.
Shunsuke ManagiUrban Institute & Department of Civil Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka-shi 819-0395, Fukuoka, Japan.
Tohru TezukaLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.
Akihiko YoshizawaDepartment of Diagnostic Pathology, Nara Medical University, 840 Shijo-cho, Kashihara-shi 634-8521, Nara, Japan.
Minsoo KimLaboratory of Integrative Molecular Medicine, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, Sakyo-ku, Kyoto-shi 606-8501, Kyoto, Japan.ORCID 0000-0001-8536-8653

Funding

Cancer Research Grants by Kyoto Preventive Medical Center XXFIMECS, Inc. XXJapan Society for the Promotion of Science JP20H02878Japan Society for the Promotion of Science JP21K19507Japan Society for the Promotion of Science JP22K16371Japan Society for the Promotion of Science JP22KK0128
6 · The paper itself

Abstract

Stromal cells play a critical role in the tumor microenvironment of breast cancer (BC), as they are recruited by tumor cells and regulate the metastatic spread. Though high expression of α-parvin, a member of the parvin family of actin-binding proteins, is reported to be associated with a poor prognosis and metastasis in several cancers, its role in carcinogenesis has not been thoroughly explored. Therefore, we aimed to examine the expression of α-parvin in BC patients by compartmentalizing and quantifying tissues to determine whether α-parvin can be a potential therapeutic target. We performed immunohistochemical (IHC) staining of α-parvin in BC tissues, and the IHC scores were calculated in the overall tissue, stroma, and epithelium using image analysis software. The expression of α-parvin was significantly higher in BC tissues (

Indexed as

Breast NeoplasmsAdultAgedBiomarkers, TumorFemaleHumansImmunohistochemistryKi-67 AntigenMicrofilament ProteinsMiddle AgedPrognosisStromal CellsTumor MicroenvironmentBiomarkers, TumorKi-67 AntigenMicrofilament Proteinsbreast cancerHALOstromaα-parvin

Identifiers

PMID39329755
PMCPMC11430769

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.