Evidence map›Paper›PMID 39329724›Full record

ArticleCells2024

Structural and Functional Characterization of the Most Frequent Pathogenic PRKN Substitution p.R275W.

Bernardo A Bustillos, Liam T Cocker, Mathew A Coban, Caleb A Weber, Jenny M Bredenberg, Paige K Boneski, Joanna Siuda, Jaroslaw Slawek, Andreas Puschmann, Derek P Narendra and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bernardo A BustillosMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Liam T CockerMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.ORCID 0009-0009-6704-2284
Mathew A CobanMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.ORCID 0000-0001-6396-6759
Caleb A WeberMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Jenny M BredenbergMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Paige K BoneskiMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Joanna SiudaDepartment of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland.ORCID 0000-0002-0340-660X
Jaroslaw SlawekDepartment of Neurology, St. Adalbert Hospital, 80-462 Gdansk, Poland.
Andreas PuschmannDepartment of Clinical Sciences, Neurology, Lund University, 22100 Lund, Sweden.ORCID 0000-0002-3201-8198
Derek P NarendraInherited Movement Disorders Unit, Neurogenetics Branch, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD 20892, USA.ORCID 0000-0002-8696-9108
Neill R Graff-RadfordMayo Clinic, Department of Neurology, Jacksonville, FL 32224, USA.
Zbigniew K WszolekMayo Clinic, Graduate School of Biomedical, Sciences Neuroscience PhD Program, Jacksonville, FL 32224, USA.ORCID 0000-0001-5487-1053
Dennis W DicksonMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Owen A RossMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.
Thomas R CaulfieldMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.ORCID 0000-0002-1055-3069
Wolfdieter SpringerMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.ORCID 0000-0002-1178-3149
Fabienne C FieselMayo Clinic, Department of Neuroscience, Jacksonville, FL 32224, USA.ORCID 0000-0002-1919-9676

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$120.9M
Utilization of proteomics and lipidomics to identify modifiers of LBDU54NS110435 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J · 2019 to 2023
$14.5M
Molecular mechanisms of PINK1-PRKN directed mitochondrial quality controlRF1NS085070 · NINDS · MAYO CLINIC JACKSONVILLE · PI SPRINGER, WOLFDIETER · 2019 to 2019
$2.8M
Mitochondrial Sirtuin 3 in Parkinson's diseaseR01NS110085 · NINDS · MAYO CLINIC JACKSONVILLE · PI MCLEAN, PAMELA J, SPRINGER, WOLFDIETER · 2019 to 2023
$2.5M
Molecular mechanisms of Parkin-directed mitochondrial quality controlR01NS085070 · NINDS · MAYO CLINIC JACKSONVILLE · PI SPRINGER, WOLFDIETER · 2014 to 2018
$1.7M
NIA NIH HHS U19 AG063911NINDS NIH HHS R01 NS085070NINDS NIH HHS R01 NS110085NINDS NIH HHS RF1 NS085070NINDS NIH HHS U54 NS110435
6 · The paper itself

Abstract

Mutations in the

Indexed as

FibroblastsMitophagyParkinson DiseaseUbiquitin-Protein LigasesBrainFemaleGTP PhosphohydrolasesHumansMaleMitochondriaMitochondrial ProteinsMutationNeuronsProtein KinasesPTEN-Induced Putative KinaseGTP PhosphohydrolasesMFN2 protein, humanMitochondrial Proteinsparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesmitophagyparkinParkinson diseasePINK1PRKNubiquitin

Identifiers

PMID39329724
PMCPMC11430725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.