Evidence map›Paper›PMID 39329707›Full record

ArticleCells2024

Concurrent Oncolysis and Neurolesion Repair by Dual Gene-Engineered hNSCs in an Experimental Model of Intraspinal Cord Glioblastoma.

Xiang Zeng, Alexander E Ropper, Zaid Aljuboori, Dou Yu, Theodore W Teng, Serdar Kabatas, Esteban Usuga, Jamie E Anderson, Yang D Teng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang ZengDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02129, USA.ORCID 0000-0003-4577-749X
Alexander E RopperDepartment of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Zaid AljubooriDepartment of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
Dou YuDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02129, USA.
Theodore W TengHarvard College, Harvard University, Cambridge, MA 02138, USA.
Serdar KabatasDepartment of Neurosurgery, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.ORCID 0000-0003-2691-6861
Esteban UsugaDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02129, USA.
Jamie E AndersonDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02129, USA.ORCID 0000-0001-7113-3933
Yang D TengDepartment of Physical Medicine and Rehabilitation, Harvard Medical School and Spaulding Rehabilitation Hospital, Boston, MA 02129, USA.

Funding

Polymer-Stabilized Mesenchymal Stem Cells for Spinal Cord RepairI01RX000308 · VA · VA BOSTON HEALTH CARE SYSTEM · PI TENG, YANG D. · 2012 to 2014
–
RRD VA I01 RX000308
6 · The paper itself

Abstract

Intramedullary spinal cord glioblastoma (ISCG) is lethal due to lack of effective treatment. We previously established a rat C6-ISCG model and the antitumor effect of F3.CD-TK, an hNSC line expressing CD and TK, via producing cytocidal 5FU and GCV-TP. However, the neurotherapeutic potential of this hNSC approach has remained uninvestigated. Here for the first time, cultured F3.CD-TK cells were found to have a markedly higher oncolytic effect, which was GJIC-dependent, and BDNF expression but less VEGF secretion than F3.CD. In Rowett athymic rats, F3.CD-TK (1.5 × 10

Indexed as

Genetic EngineeringGlioblastomaSpinal Cord NeoplasmsAnimalsCell Line, TumorDisease Models, AnimalHumansRatsRats, Nudeautonomic dysfunctiongene-directed enzyme prodrug therapy/GDEPTglioblastomaintramedullary spinal cord tumorlocomotionneural stem cells

Identifiers

PMID39329707
PMCPMC11429792

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.