Evidence map›Paper›PMID 39329627›Full record

ArticleBioengineering (Basel, Switzerland)2024

A Novel High-Throughput and Sensitive Electrochemiluminescence Immunoassay System.

Xiancheng Liu, Shuang Zhao, Yan Xu, Bo Zhang, Junli Huang, Feng Liu, Ning Yang, Wenhua Lu, Dandan Shi, Dezhong Xie and 2 more

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiancheng LiuKey Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Shuang ZhaoKey Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Yan XuKey Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Bo ZhangKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Junli HuangKey Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.
Feng LiuKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Ning YangKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Wenhua LuKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Dandan ShiKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Dezhong XieKey Technology Engineering Laboratory of Immunoassay and Liquid Chromatography In Vitro Diagnosis in Shenzhen, Lifotronic Technology Co., Ltd., Shenzheng 518005, China.
Yuanfang HouChongqing Engineering Research Center of Pharmaceutical Sciences, Pharmaceutical College, Chongqing 401331, China.
Guixue WangKey Laboratory for Biorheological Science and Technology of Ministry of Education, National and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400044, China.ORCID 0000-0002-9192-8757

Funding

the Fundamental Research Funds for the Central Universities No.2024CDJCGJ-016the National Natural Science Foundation of China 12032007the Science and Technology Innovation Project of JinFeng Laboratory, Chongqing No.jfkyjf202203001
6 · The paper itself

Abstract

(1) Background: In vitro diagnostic (IVD) tests are the main means of obtaining diagnostic information for clinical purposes. The electrochemiluminescence immunoassay (ECLIA) has become an important in vitro diagnostic technique. It has unique advantages and broad market prospects due to its sensitivity, detection limit, detection range and reagent stability. At present, there is a need to develop and optimize electrochemiluminescence immunoassay subsystems to achieve high-throughput outputs and accurate detection of instruments to promote their clinical application. (2) Methods: On the basis of the demand for clinical testing instruments with high detection accuracy and speed, this study constructed an electrochemiluminescence immunoassay system by designing magnetic separation modules, introducing PMT and optimizing the system timing regulation capability. (3) Results: The magnetic separation modules can increase the detection accuracy, the PMT system increases the detection sensitivity and optimized system timing can achieve maximum test output. Furthermore, this system performs well in terms of its linearity, detection limit, signal-to-noise ratio, precision and accuracy. (4) Conclusions: The electrochemiluminescence immunoassay system is capable of high throughput with good sensitivity and accuracy, meeting the basic requirements of clinical applications for detection capacity and output throughput.

Indexed as

compensation systemelectrochemiluminescence immunoassay systemmagnetic separationsystem timing module

Identifiers

PMID39329627
PMCPMC11428954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.