Evidence map›Paper›PMID 39329487›Full record

ArticleApplied and environmental microbiology2024

A gene regulating ergot alkaloid biosynthesis in

Samantha J Fabian, Chey R Steen, F Heath Damron, Celeste A DeRiggi, Daniel G Panaccione

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samantha J FabianDivision of Plant and Soil Sciences, West Virginia University, Morgantown, West Virginia, USA.
Chey R SteenDivision of Plant and Soil Sciences, West Virginia University, Morgantown, West Virginia, USA.
F Heath DamronDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-3140-402X
Celeste A DeRiggiDivision of Plant and Soil Sciences, West Virginia University, Morgantown, West Virginia, USA.
Daniel G PanaccioneDivision of Plant and Soil Sciences, West Virginia University, Morgantown, West Virginia, USA.ORCID 0000-0002-4159-164X

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Strategic Reprogramming of the Ergot Alkaloid PathwayR15GM114774 · NIGMS · WEST VIRGINIA UNIVERSITY · PI PANACCIONE, DANIEL G. · 2015 to 2023
$1.3M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R15GM114774NIGMS NIH HHS R15 GM114774NIGMS NIH HHS U54 GM104942U.S. Department of Agriculture (USDA) NC1183
6 · The paper itself

Abstract

Ergot alkaloid synthesis ( IMPORTANCE: Ergot alkaloids produced by several species of fungi are important as contaminants of food and feed in agriculture and also as the foundation of numerous pharmaceuticals prescribed for dementia, migraines, hyperprolactinemia, and several other disorders. Information on control of the ergot alkaloid pathway may contribute to strategies to limit their production in agricultural settings or increase their yield for pharmaceutical production. Our results demonstrate that a previously uncharacterized gene clustered with the ergot alkaloid synthesis genes is required for the sufficient transcription of the ergot alkaloid biosynthesis genes. This observation suggests the gene encodes a factor regulating transcription of those biosynthetic genes.

Indexed as

Ergot AlkaloidsFungal ProteinsLarvaMetarhiziumAnimalsGene Expression Regulation, FungalGene Knockout TechniquesMothsMultigene FamilyErgot AlkaloidsFungal Proteinsbiosynthetic gene clusterClavicipitaceaeergot alkaloidslysergic acid amidesMetarhizium

Identifiers

PMID39329487
PMCPMC11497822

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.