Evidence map›Paper›PMID 39329353›Full record

ArticleBiotechnology progress

CHO stable pool fed-batch process development of SARS-CoV-2 spike protein production: Impact of aeration conditions and feeding strategies.

Sebastian-Juan Reyes, Phuong Lan Pham, Yves Durocher, Olivier Henry

Abstract read
In one paragraph

Article in Biotechnology progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sebastian-Juan ReyesDepartment of Chemical Engineering, Polytechnique Montreal, Quebec, Canada.
Phuong Lan PhamHuman Health Therapeutics Research Centre, National Research Council Canada, Montréal, Quebec, Canada.
Yves DurocherHuman Health Therapeutics Research Centre, National Research Council Canada, Montréal, Quebec, Canada.
Olivier HenryDepartment of Chemical Engineering, Polytechnique Montreal, Quebec, Canada.ORCID 0000-0003-2106-1331

Funding

National Research Council Canada PR-023-1Natural Sciences and Engineering Research Council of Canada RGPIN-40482021
6 · The paper itself

Abstract

Technology scale-up and transfer are a fundamental and critical part of process development in biomanufacturing. Important bioreactor hydrodynamic characteristics such as working volume, overhead gas flow rate, volumetric power input (P/V), impeller type, agitation regimen, sparging aeration strategy, sparger type, and k

Indexed as

Batch Cell Culture TechniquesSARS-CoV-2Spike Glycoprotein, CoronavirusAnimalsBioreactorsCHO CellsCOVID-19CricetinaeCricetulusOxygenOxygenSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2bio‐capacitanceCHO stable poolfed‐batch process developmentfeeding strategyoxygen uptake rateSARS‐CoV‐2 vaccine antigen

Identifiers

PMID39329353
PMCPMC11831418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.