Evidence map›Paper›PMID 39329328›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2024

Novel hybrids of 1,2,3-triazole-benzoxazole: design, synthesis, and assessment of DprE1 enzyme inhibitors using fluorometric assay and computational analysis.

Manisha Singh, Sarah M Batt, Christian S C Canales, Fernando R Pavan, Sethu Arun Kumar, Handattu S Akshatha, Meduri Bhagyalalitha, Karthik G Pujar, Durgesh Bidye, Gurubasavaraj V Pujar and 1 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. [Fe(phen)ACS omega · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manisha SinghComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Sarah M BattSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Christian S C CanalesFaculty of Pharmaceutical Sciences, Paulista State University-UNESP, Araraquara, SP, Brazil.
Fernando R PavanFaculty of Pharmaceutical Sciences, Paulista State University-UNESP, Araraquara, SP, Brazil.
Sethu Arun KumarComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Handattu S AkshathaComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Meduri BhagyalalithaComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Karthik G PujarComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Durgesh BidyeComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Gurubasavaraj V PujarComputer Aided Drug Design Lab, Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysore, India.
Gurdyal S BesraSchool of Biosciences, University of Birmingham, Birmingham, United Kingdom.ORCID 0000-0002-5605-0395

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Decaprenylphosphoryl-β-D-ribose-oxidase (DprE1), a subunit of the essential decaprenylphosphoribose-2'-epimerase, plays a crucial role in the synthesis of cell wall arabinan components in mycobacteria, including the pathogen responsible for tuberculosis,

Indexed as

BenzoxazolesDose-Response Relationship, DrugDrug DesignEnzyme InhibitorsMycobacterium tuberculosisTriazolesAlcohol OxidoreductasesBacterial ProteinsFluorometryMicrobial Sensitivity TestsModels, MolecularMolecular StructureStructure-Activity RelationshipAlcohol OxidoreductasesBacterial ProteinsBenzoxazolesDprE1 protein, Mycobacterium tuberculosisEnzyme InhibitorsTriazoles1,2,3-triazolesDprE1 inhibitor assayTuberculosis

Identifiers

PMID39329328
PMCPMC11441021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.