Evidence map›Paper›PMID 39329081›Full record

ArticleBrain communications2024

Children born very preterm experience altered cortical expansion over the first decade of life.

Lisa S Gorham, Aidan R Latham, Dimitrios Alexopoulos, Jeanette K Kenley, Emily Iannopollo, Rachel E Lean, David Loseille, Tara A Smyser, Jeffrey J Neil, Cynthia E Rogers and 2 more

Abstract read
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisa S GorhamDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0002-5150-8176
Aidan R LathamDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dimitrios AlexopoulosDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeanette K KenleyDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Emily IannopolloDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rachel E LeanDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID https://orcid.org/0000-0001-5179-0282
David LoseilleDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Tara A SmyserDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jeffrey J NeilDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Cynthia E RogersDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Christopher D SmyserDepartment of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Kara GarciaDepartment of Radiology & Imaging Sciences, Indiana University School of Medicine, Evansville, IN 46202, USA.

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Neuroscience Training Program at Washington UniversityT32NS121881 · NINDS · WASHINGTON UNIVERSITY · PI Martha W Bagnall, Daniel Kerschensteiner · 2021 to 2026
$3.1M
THE PRETERM BEHAVIORAL PHENOTYPE: TRAJECTORIES OF PSYCHOPATHOLOGY & CHANGES IN CEREBRAL CONNECTIVITYR01MH113570 · NIMH · WASHINGTON UNIVERSITY · PI ROGERS, CYNTHIA ELISE, SMYSER, CHRISTOPHER DANIEL · 2017 to 2021
$3.1M
Investigating Links Between Dysfunctional Parenting and Infant Brain Connectivity on Development of Effortful ControlK01MH122735 · NIMH · WASHINGTON UNIVERSITY · PI LEAN, RACHEL EMMA · 2021 to 2025
$881k
NICHD NIH HHS P50 HD103525NIMH NIH HHS K01 MH122735NIMH NIH HHS R01 MH113570NINDS NIH HHS T32 NS121881
6 · The paper itself

Abstract

The brain develops rapidly from the final trimester of gestation through childhood, with cortical surface area expanding greatly in the first decade of life. However, it is unclear exactly where and how cortical surface area changes after birth, or how prematurity affects these developmental trajectories. Fifty-two very preterm (gestational age at birth = 26 ± 1.6 weeks) and 41 full-term (gestational age at birth = 39 ± 1.2 weeks) infants were scanned using structural magnetic resonance imaging at term-equivalent age and again at 9/10 years of age. Individual cortical surface reconstructions were extracted for each scan. Infant and 9/10 cortical surfaces were aligned using anatomically constrained Multimodal Surface Matching (aMSM), a technique that allows calculation of local expansion gradients across the cortical surface for each individual subject. At the neonatal time point, very preterm infants had significantly smaller surface area than their full-term peers (

Indexed as

brain developmentcortical expansionprematuritysurface area

Identifiers

PMID39329081
PMCPMC11426356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.