Evidence map›Paper›PMID 39328978›Full record

ArticleHealth science reports2024

Neonatal sex and maternal factors associated with small-for-gestational-age neonates: A nationwide population-based study.

Pei-Han Fu, Chia-Hung Yu, Hao-Wei Chung, Pei-Hua Wu, Chiao-Yun Huang, Fu-Wen Liang

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Article in Health science reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Pei-Han FuDepartment of Anaesthesiology Chi Mei Medical Centre Tainan Taiwan.ORCID 0009-0007-3411-5382
Chia-Hung YuDepartment of Anaesthesiology Chi Mei Medical Centre Tainan Taiwan.
Hao-Wei ChungDepartment of Paediatrics, Kaohsiung Medical University Hospital Kaohsiung Medical University Kaohsiung Taiwan.ORCID 0000-0001-5159-1427
Pei-Hua WuDepartment of Public Health, College of Health Sciences Kaohsiung Medical University Kaohsiung Taiwan.
Chiao-Yun HuangDepartment of Public Health, College of Health Sciences Kaohsiung Medical University Kaohsiung Taiwan.
Fu-Wen LiangDepartment of Public Health, College of Health Sciences Kaohsiung Medical University Kaohsiung Taiwan.ORCID 0000-0002-3396-037X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: Small-for-gestational-age (SGA) newborns have a higher risk of morbidity and mortality. Recognizing the risk factors for SGA helps raise early awareness of the issue and provides valuable insights for both healthcare providers and pregnant women. We aimed to identify determinants of SGA using population-based databases in Taiwan. Methods: Data were retrieved from the National Health Insurance, Birth Reporting, and Maternal and Child Health databases for this nationwide case-control study. Live births between 20 and 44 weeks of gestation from 2005 to 2014 were enrolled and linked to their mothers to determine maternal conditions during pregnancy. For every SGA newborn, four controls matched by gestational age and birth year were randomly selected. Multivariable logistic regression was used to identify risk factors for SGA, with adjusted odds ratios (aORs) and 95% confidence intervals (CIs) accounting for potential confounders and interaction terms. Results: A total of 158,405 live SGA births were identified, with 623,584 controls randomly selected. Independent risk factors for SGA included maternal age <20 years (aOR 1.68, 95% CI 1.62, 1.75); female sex in newborns (aOR 1.28, 95% CI 1.27, 1.30); socioeconomic deprivation (aOR 1.29, 95% CI 1.21, 1.38); hypertension (aOR 1.6, 95% CI 1.52, 1.67); kidney disorders (aOR 1.29, 95% CI 1.16, 1.44); thyroid disorders (aOR 1.13, 95% CI 1.09, 1.17); systemic lupus erythematosus (aOR 2.59, 95% CI 2.33, 2.89); antiphospholipid syndrome (aOR 2.08, 95% CI 1.64, 2.64); gestational hypertension (aOR 1.69, 95% CI 1.61, 1.76); pre-eclampsia (aOR 3.12, 95% CI 3.01, 3.25); and antepartum hemorrhage (aOR 1.05, 95% CI 1.03, 1.07) after adjustment for other covariates. Conclusions: SGA was associated with younger maternal age, female newborns, underlying comorbidities, and obstetric conditions. Gestational hypertension and pre-eclampsia were significant risk factors affecting infants of both sexes and all age groups and could mask the effects of maternal age and infant sex.

Indexed as

live birthneonatenewbornrisk factorssmall‐for‐gestational‐age

Identifiers

PMID39328978
PMCPMC11424293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.