Evidence map›Paper›PMID 39328899›Full record

ArticleResuscitation plus2024

Hypoxic-ischemic brain injury in pig after cardiac arrest - A new histopathological scoring system for non-specialists.

Miriam Renz, Pascal Siegert, Roman Paul, Adina Lepadatu, Petra Leukel, Katrin Frauenknecht, Andrea Urmann, Johanna Hain, Katja Mohnke, Alexander Ziebart and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Miriam RenzDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Pascal SiegertDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Roman PaulInstitute for Medical Biometry, Epidemiology and Information Technology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Adina LepadatuInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Petra LeukelInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Katrin FrauenknechtInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Andrea UrmannDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Johanna HainDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Katja MohnkeDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Alexander ZiebartDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Anja HarderInstitute of Neuropathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany.
Robert RuemmlerDepartment of Anesthesiology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: After cardiac arrest and successful resuscitation patients often present with hypoxic-ischemic brain injury, which is a major cause of death due to poor neurological outcome. The development of a robust histopathological scoring system for the reliable and easy identification and quantification of hypoxic-ischemic brain injury could lead to a standardization in the evaluation of brain damage. We wanted to establish an easy-to-use neuropathological scoring system to identify and quantify hypoxic-ischemic brain injury. Methods: The criteria for regular neurons, hypoxic-ischemic brain injury neurons and neurons with ischemic neuronal change (ischemic change neurons) were established in collaboration with specialized neuropathologists. Nine non-specialist examiners performed cell counting using the mentioned criteria in brain tissue samples from a porcine cardiac arrest model. The statistical analyses were performed using the interclass correlation coefficient for counting data and reliability testing. Results: The inter-rater reliability for regular neurons (ICC 0.68 (0.42 - 0.84; p < 0.001) and hypoxic-ischemic brain injury neurons (ICC 0.87 (0.81 - 0.92; p < 0.001) showed moderate to excellent correlation while ischemic change neurons showed poor reliability. Excellent results were seen for intra-rater reliability for regular neurons (ICC 0.9 (0.68 - 0.97; p < 0.001) and hypoxic-ischemic brain injury neurons (ICC 0.99 (0.83 - 1; p < 0.001). Conclusion: The scoring system provides a reliable method for the discrimination between regular neurons and neurons affected by hypoxic/ischemic injury. This scoring system allows an easy and reliable identification and quantification of hypoxic-ischemic brain injury for non-specialists and offers a standardization to evaluate hypoxic-ischemic brain injury after cardiac arrest.

Indexed as

Cardiac arrestHypoxic-ischemic brain injuryPorcine studiesResuscitationScoring hypoxia

Identifiers

PMID39328899
PMCPMC11424782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.