Evidence map›Paper›PMID 39328410›Full record

ArticleFrontiers in immunology2024

Role of circulating T follicular helper subsets following Ty21a immunization and oral challenge with wild type

Jayaum S Booth, Rekha R Rapaka, Monica A McArthur, Stephanie Fresnay, Thomas C Darton, Christoph J Blohmke, Claire Jones, Claire S Waddington, Myron M Levine, Andrew J Pollard and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jayaum S BoothCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Rekha R RapakaCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Monica A McArthurCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Stephanie FresnayCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Thomas C DartonOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the National Institute for Health and Care Research (NIHR), Oxford Biomedical Research Centre, Oxford, United Kingdom.
Christoph J BlohmkeOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the National Institute for Health and Care Research (NIHR), Oxford Biomedical Research Centre, Oxford, United Kingdom.
Claire JonesOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the National Institute for Health and Care Research (NIHR), Oxford Biomedical Research Centre, Oxford, United Kingdom.
Claire S WaddingtonOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the National Institute for Health and Care Research (NIHR), Oxford Biomedical Research Centre, Oxford, United Kingdom.
Myron M LevineCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
Andrew J PollardOxford Vaccine Group, Department of Pediatrics, University of Oxford, and the National Institute for Health and Care Research (NIHR), Oxford Biomedical Research Centre, Oxford, United Kingdom.
Marcelo B SzteinCenter for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2003 to 2013
$91.5M
Leadership Group for the Infectious Diseases Clinical Research Consortium (IDCRCLG) - Momi-Vax DMID #21-0004 {Supplement #6}UM1AI148684 · NIAID · EMORY UNIVERSITY · PI DAVID S STEPHENS · 2020 to 2026
$77.2M
UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Wild-type S. typhi Infection in Humans: Integrated Immunoprotective MechanismsU19AI082655 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FRASER, CLAIRE M. · 2009 to 2018
$27.8M
Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Probiotic yeast secreting single-domain antibodies to prevent Clostridium difficile and Campylobacter jejuni diseaseU19AI142725 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI SZTEIN, MARCELO B. · 2019 to 2023
$12.5M
IMMUNE MECHANISMS OF PROTECTION IN S TYPHI VACCINESR01AI036525 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Marcelo B. Sztein · 1994 to 2026
$12.2M
Systems Biology and Biostatistics CoreU19AI181108 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Rosangela Mezghanni · 2024 to 2026
$8.0M
Human Cellular Immune Programming Against Invasive SalmonellaK08AI143923 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RAPAKA, REKHA R · 2019 to 2023
$798k
NCI NIH HHS P30 CA134274NIAID NIH HHS K08 AI143923NIAID NIH HHS R01 AI036525NIAID NIH HHS U19 AI082655NIAID NIH HHS U19 AI109776NIAID NIH HHS U19 AI142725NIAID NIH HHS U19 AI181108NIAID NIH HHS U54 AI057168NIAID NIH HHS UM1 AI148684
6 · The paper itself

Abstract

Despite decades of intense research, our understanding of the correlates of protection against

Indexed as

Salmonella typhiT Follicular Helper CellsTyphoid FeverTyphoid-Paratyphoid VaccinesAdministration, OralAdolescentAdultAntibodies, BacterialFemaleHumansImmunizationMalePolysaccharides, BacterialYoung AdultAntibodies, BacterialPolysaccharides, BacterialTy21a typhoid vaccineTyphoid-Paratyphoid VaccinesCHIMcirculating follicular helper T cellscTfhS. Typhityphoid fever

Identifiers

PMID39328410
PMCPMC11424897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.